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- W2034194669 abstract "A panel of anomeric oxime ether derivatives of beta-galactose were synthesized via the reaction of O-beta-D-galactopyranosylhydroxylamine with aldehydes. The oxime ethers were evaluated as inhibitors against galectin-3 in a competitive fluorescence polarization assay. The best inhibitor, [E]-O-(beta-D-galactopyranosyl)-indole-3-carbaldoxime (E-52), had a Kd value of 180 microM, which is 24 times better than methyl beta-D-galactopyranoside (Kd=4400 microM) and in the same range as methyl lactoside (Kd=220 microM)." @default.
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- W2034194669 date "2005-05-01" @default.
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- W2034194669 title "Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors" @default.
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- W2034194669 doi "https://doi.org/10.1016/j.bmcl.2005.02.079" @default.
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