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• W2034194679 endingPage "275" @default.
• W2034194679 startingPage "267" @default.
• W2034194679 abstract "1 Leukotriene C4 (LTC4), LTD4, slow-reacting substance of anaphylaxis (SRS-A) (from guinea-pig lung), bradykinin (Bk) and arachidonic acid (AA) release thromboxane A2 (TxA2) and prostaglandin-like materials from guinea-pig isolated perfused lungs. 2 Release of TxA2 induced by LTC4 and LTD4 is inhibited by a thromboxane synthetase inhibitor, imidazole (2.9 mM). 3 Mepacrine (200 microM), a phospholipase inhibitor, inhibits release of TxA2 and prostaglandin-like materials caused by SRS-A and Bk but not that due to exogenous AA 4 Leukotrienes B4, C4 and D4 are approximately equipotent in inducing dose-related contractions of guinea-pig parenchymal strips (GPPs). 5 Leukotriene-induced contractions of GPPs are greatly inhibited by imidazole (2.9 mM), carboxyheptylimidazole (24 microM) and mepacrine (400 microM). 6 FPL 55712 (1.9 microM), the SRS-A antagonist, blocks contractions of GPPs induced by LTC4 and LTD4 but not those due to LTB4 or Bk. 7 Tachyphylaxis to LTB4 occurs in GPPs but not to LTC4 or LTD4. 8 These results suggest that in guinea-pig lung in vitro, LTB4, LTC4 and LTD4 activate a phospholipase with subsequent generation of cyclo-oxygenase products of which TxA2 plays an important role." @default.
• W2034194679 created "2016-06-24" @default.
• W2034194679 creator A5010829130 @default.
• W2034194679 creator A5017846395 @default.
• W2034194679 date "1982-10-01" @default.
• W2034194679 modified "2023-10-14" @default.
• W2034194679 title "STIMULATION OF ARACHIDONIC ACID METABOLISM AND GENERATION OF THROMBOXANE A2 BY LEUKOTRIENES B4, C4 AND D4 IN GUINEA-PIG LUNG in vitro" @default.
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• W2034194679 doi "https://doi.org/10.1111/j.1476-5381.1982.tb09295.x" @default.
• W2034194679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2044593" @default.
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