Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034194796> ?p ?o ?g. }
- W2034194796 endingPage "444" @default.
- W2034194796 startingPage "438" @default.
- W2034194796 abstract "The human fetus and neonate swallow biologically significant quantities of IL-8/CXC ligand 8 (CXCL8) in amniotic fluid and breast milk, and this remains measurable through simulated neonatal gastric and proximal intestinal digestions. We sought to confirm the structural and functional integrity of IL-8/CXCL8 in digestates and determine the mechanisms underlying this protease resistance. We observed that in comparison with BSA, IL-8/CXCL8 is highly resistant to pepsin and can be detected intact in assays for structural, immunologic, and functional integrity. In a computational molecular docking simulation, IL-8/CXCL8 was observed to fit poorly in the pepsin active site. On the basis of simulated mutation analyses, we hypothesized that this protease resistance is due to disulfide bond-related tertiary folding in IL-8/CXCL8. This was confirmed on chemical reduction of these groups." @default.
- W2034194796 created "2016-06-24" @default.
- W2034194796 creator A5020051097 @default.
- W2034194796 creator A5026854749 @default.
- W2034194796 creator A5033855623 @default.
- W2034194796 creator A5061379138 @default.
- W2034194796 creator A5083719128 @default.
- W2034194796 date "2005-03-01" @default.
- W2034194796 modified "2023-10-10" @default.
- W2034194796 title "IL-8/CXC Ligand 8 Survives Neonatal Gastric Digestion as a Result of Intrinsic Aspartyl Proteinase Resistance" @default.
- W2034194796 cites W1547929361 @default.
- W2034194796 cites W1598918842 @default.
- W2034194796 cites W1666643260 @default.
- W2034194796 cites W1866330001 @default.
- W2034194796 cites W1944338891 @default.
- W2034194796 cites W1968173020 @default.
- W2034194796 cites W1982405838 @default.
- W2034194796 cites W1983725231 @default.
- W2034194796 cites W1997764055 @default.
- W2034194796 cites W1999548772 @default.
- W2034194796 cites W2003951221 @default.
- W2034194796 cites W2015642465 @default.
- W2034194796 cites W2019011307 @default.
- W2034194796 cites W2025295118 @default.
- W2034194796 cites W2028659951 @default.
- W2034194796 cites W2037365087 @default.
- W2034194796 cites W2039952200 @default.
- W2034194796 cites W2040446474 @default.
- W2034194796 cites W2052794591 @default.
- W2034194796 cites W2055003760 @default.
- W2034194796 cites W2055238564 @default.
- W2034194796 cites W2056628056 @default.
- W2034194796 cites W2058519081 @default.
- W2034194796 cites W2058522802 @default.
- W2034194796 cites W2063581768 @default.
- W2034194796 cites W2064118723 @default.
- W2034194796 cites W2067696053 @default.
- W2034194796 cites W2071766396 @default.
- W2034194796 cites W2075219502 @default.
- W2034194796 cites W2075732858 @default.
- W2034194796 cites W2078460356 @default.
- W2034194796 cites W2087330221 @default.
- W2034194796 cites W2087472718 @default.
- W2034194796 cites W2090782244 @default.
- W2034194796 cites W2092066028 @default.
- W2034194796 cites W2093547815 @default.
- W2034194796 cites W2123690308 @default.
- W2034194796 cites W2128172847 @default.
- W2034194796 cites W2130479394 @default.
- W2034194796 cites W2131124255 @default.
- W2034194796 cites W2131627639 @default.
- W2034194796 cites W2132717858 @default.
- W2034194796 cites W2148696721 @default.
- W2034194796 cites W2155196408 @default.
- W2034194796 cites W2158714788 @default.
- W2034194796 cites W2161390969 @default.
- W2034194796 cites W2165035813 @default.
- W2034194796 cites W4231044539 @default.
- W2034194796 doi "https://doi.org/10.1203/01.pdr.0000151317.08180.7e" @default.
- W2034194796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15585673" @default.
- W2034194796 hasPublicationYear "2005" @default.
- W2034194796 type Work @default.
- W2034194796 sameAs 2034194796 @default.
- W2034194796 citedByCount "7" @default.
- W2034194796 countsByYear W20341947962014 @default.
- W2034194796 countsByYear W20341947962016 @default.
- W2034194796 countsByYear W20341947962018 @default.
- W2034194796 crossrefType "journal-article" @default.
- W2034194796 hasAuthorship W2034194796A5020051097 @default.
- W2034194796 hasAuthorship W2034194796A5026854749 @default.
- W2034194796 hasAuthorship W2034194796A5033855623 @default.
- W2034194796 hasAuthorship W2034194796A5061379138 @default.
- W2034194796 hasAuthorship W2034194796A5083719128 @default.
- W2034194796 hasBestOaLocation W20341947961 @default.
- W2034194796 hasConcept C126322002 @default.
- W2034194796 hasConcept C16311235 @default.
- W2034194796 hasConcept C181199279 @default.
- W2034194796 hasConcept C185592680 @default.
- W2034194796 hasConcept C2776714187 @default.
- W2034194796 hasConcept C2778690821 @default.
- W2034194796 hasConcept C55493867 @default.
- W2034194796 hasConcept C68324877 @default.
- W2034194796 hasConcept C71924100 @default.
- W2034194796 hasConceptScore W2034194796C126322002 @default.
- W2034194796 hasConceptScore W2034194796C16311235 @default.
- W2034194796 hasConceptScore W2034194796C181199279 @default.
- W2034194796 hasConceptScore W2034194796C185592680 @default.
- W2034194796 hasConceptScore W2034194796C2776714187 @default.
- W2034194796 hasConceptScore W2034194796C2778690821 @default.
- W2034194796 hasConceptScore W2034194796C55493867 @default.
- W2034194796 hasConceptScore W2034194796C68324877 @default.
- W2034194796 hasConceptScore W2034194796C71924100 @default.
- W2034194796 hasIssue "3" @default.
- W2034194796 hasLocation W20341947961 @default.
- W2034194796 hasLocation W20341947962 @default.
- W2034194796 hasOpenAccess W2034194796 @default.
- W2034194796 hasPrimaryLocation W20341947961 @default.
- W2034194796 hasRelatedWork W198034794 @default.