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• W203419568 abstract "Research Article3 January 1995free access Periodic cdc25C transcription is mediated by a novel cell cycle-regulated repressor element (CDE). F.C. Lucibello F.C. Lucibello Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author M. Truss M. Truss Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author J. Zwicker J. Zwicker Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author F. Ehlert F. Ehlert Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author M. Beato M. Beato Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author R. Müller R. Müller Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author F.C. Lucibello F.C. Lucibello Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author M. Truss M. Truss Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author J. Zwicker J. Zwicker Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author F. Ehlert F. Ehlert Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author M. Beato M. Beato Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author R. Müller R. Müller Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. Search for more papers by this author Author Information F.C. Lucibello1, M. Truss1, J. Zwicker1, F. Ehlert1, M. Beato1 and R. Müller1 1Institut für Molekularbiologie und Tumorforschung (IMT), Phillipps-Universität Marburg, Germany. The EMBO Journal (1995)14:132-142https://doi.org/10.1002/j.1460-2075.1995.tb06983.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We show that the cell cycle-regulated transcription of the TATA-less cdc25C gene in late S/G2 is largely mediated by a novel promoter element (CDE) located directly 5′ to one of the two major transcription initiation sites. Genomic dimethylsulfate footprinting experiments, using either synchronized or sorted normally cycling cells, show the formation in vivo of a CDE-protein complex in both G0 and G1 cells and its dissociation in G2. Mutation of the CDE severely impairs cell cycle regulation of the cdc25C promoter and results in high expression in G0/G1, indicating that the CDE functions as a cell cycle-regulated cis-acting repressor element. Cell cycle regulation is also lost upon removal of the enhancer region located immediately upstream of the CDE, but is largely restored when this enhancerless minimal cdc25C promoter fragment is linked to the constitutive SV40 early enhancer. This indicates that the CDE is dependent on the presence of a transcriptional enhancer to effect cell cycle regulation. Our observations suggest that the periodic activation of the cdc25C gene in late S/G2 is brought about, at least in part, by a unique regulatory mechanism involving the cell cycle-regulated dissociation of a repressor from the CDE. Previous ArticleNext Article Volume 14Issue 11 January 1995In this issue RelatedDetailsLoading ..." @default.
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• W203419568 title "Periodic cdc25C transcription is mediated by a novel cell cycle-regulated repressor element (CDE)." @default.
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• W203419568 cites W2009389356 @default.
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• W203419568 cites W2016189963 @default.
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• W203419568 cites W2018563836 @default.
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• W203419568 doi "https://doi.org/10.1002/j.1460-2075.1995.tb06983.x" @default.
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