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• W2034196029 abstract "Structural modification of the peptide backbone via N-methylation is a powerful tool to modulate the pharmacokinetic profile and biological activity of peptides. Here we describe a rapid and highly efficient microwave(MW)-assisted Fmoc/tBu solid-phase method to prepare short chain N-methyl-rich peptides, using Rink amide p-methylbenzhydrylamine (MBHA) resin as solid-phase support. This method produces peptides in high yield and purity, and reduces the time required for Fmoc-N-methyl amino acid coupling. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd." @default.
• W2034196029 created "2016-06-24" @default.
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• W2034196029 date "2010-02-02" @default.
• W2034196029 modified "2023-10-16" @default.
• W2034196029 title "A convenient microwave-enhanced solid-phase synthesis of short chain <i>N</i> -methyl-rich peptides" @default.
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• W2034196029 doi "https://doi.org/10.1002/psc.1209" @default.
• W2034196029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20127857" @default.
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