FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034196630> ?p ?o ?g. }

• W2034196630 endingPage "3983" @default.
• W2034196630 startingPage "3977" @default.
• W2034196630 abstract "Inflammatory cytokines such as TNF alpha may play a role in the pathogenesis of common metabolic disorders, including hyperandrogenism and the polycystic ovary syndrome (PCOS). The TNF receptor 2 mediates most of the metabolic effects of TNF alpha. In the present study, we have evaluated serum soluble TNF receptor 2 levels, and several common polymorphisms in the TNF receptor 2 gene (TNFRSF1B), in women presenting with PCOS or hyperandrogenic disorders. Initial studies included 103 hyperandrogenic patients (42 presenting with PCOS) and 36 controls from Spain. The 196R alleles of the M196R (676 T-->G) variant in exon 6 of TNFRSF1B, which is in linkage disequilibrium with a CA-repeat microsatellite polymorphism in intron 4 of TNFRSF1B, tended to be more frequent in hyperandrogenic patients than in controls (P = 0.056), reaching statistical significance when the analysis was restricted to include only PCOS patients (P < 0.03). Extended analysis including another 11 hyperandrogenic patients from Spain and 64 patients and 29 controls from Italy confirmed the association between 196R alleles of the M196R variant and hyperandrogenic disorders (P < 0.05), which was maintained when restricting the analysis to PCOS patients (P < 0.02). On the contrary, the 3'-untranslated region (exon 10) variants 1663 G-->A, 1668 T-->G, and 1690 T-->C were not associated with hyperandrogenism. The soluble TNF receptor 2 levels were not different between patients and controls but were increased in obese subjects, compared with lean individuals, and were affected by the interaction between the 1663 G-->A and 1668 T-->G variants in the 3'-untranslated region of TNFRSF1B. The TNFRSF1B genotype did not influence any clinical or biochemical variable related to hyperandrogenism or insulin sensitivity and was not associated with obesity, both in hyperandrogenic patients and healthy controls considered separately. In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders." @default.
• W2034196630 created "2016-06-24" @default.
• W2034196630 creator A5010996262 @default.
• W2034196630 creator A5054407791 @default.
• W2034196630 creator A5070575367 @default.
• W2034196630 creator A5079074403 @default.
• W2034196630 creator A5081765313 @default.
• W2034196630 date "2002-08-01" @default.
• W2034196630 modified "2023-10-15" @default.
• W2034196630 title "The Methionine 196 Arginine Polymorphism in Exon 6 of the TNF Receptor 2 Gene (TNFRSF1B) Is Associated with the Polycystic Ovary Syndrome and Hyperandrogenism" @default.
• W2034196630 cites W1483604492 @default.
• W2034196630 cites W1704134691 @default.
• W2034196630 cites W1971762417 @default.
• W2034196630 cites W1977681402 @default.
• W2034196630 cites W2012389967 @default.
• W2034196630 cites W2017374429 @default.
• W2034196630 cites W2026610862 @default.
• W2034196630 cites W2030585847 @default.
• W2034196630 cites W2032810604 @default.
• W2034196630 cites W2053200285 @default.
• W2034196630 cites W2068103783 @default.
• W2034196630 cites W2082813709 @default.
• W2034196630 cites W2098247759 @default.
• W2034196630 cites W2110649443 @default.
• W2034196630 cites W2113851528 @default.
• W2034196630 cites W2120282627 @default.
• W2034196630 cites W2120456614 @default.
• W2034196630 cites W2120897861 @default.
• W2034196630 cites W2128042308 @default.
• W2034196630 cites W2135442422 @default.
• W2034196630 cites W2141444020 @default.
• W2034196630 cites W215143088 @default.
• W2034196630 cites W2152576749 @default.
• W2034196630 cites W2162656570 @default.
• W2034196630 cites W2166252747 @default.
• W2034196630 cites W2168847507 @default.
• W2034196630 cites W2336449142 @default.
• W2034196630 cites W4236089351 @default.
• W2034196630 cites W2044087394 @default.
• W2034196630 doi "https://doi.org/10.1210/jcem.87.8.8715" @default.
• W2034196630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12161545" @default.
• W2034196630 hasPublicationYear "2002" @default.
• W2034196630 type Work @default.
• W2034196630 sameAs 2034196630 @default.
• W2034196630 citedByCount "74" @default.
• W2034196630 countsByYear W20341966302012 @default.
• W2034196630 countsByYear W20341966302014 @default.
• W2034196630 countsByYear W20341966302015 @default.
• W2034196630 countsByYear W20341966302016 @default.
• W2034196630 countsByYear W20341966302017 @default.
• W2034196630 countsByYear W20341966302019 @default.
• W2034196630 countsByYear W20341966302021 @default.
• W2034196630 countsByYear W20341966302022 @default.
• W2034196630 countsByYear W20341966302023 @default.
• W2034196630 crossrefType "journal-article" @default.
• W2034196630 hasAuthorship W2034196630A5010996262 @default.
• W2034196630 hasAuthorship W2034196630A5054407791 @default.
• W2034196630 hasAuthorship W2034196630A5070575367 @default.
• W2034196630 hasAuthorship W2034196630A5079074403 @default.
• W2034196630 hasAuthorship W2034196630A5081765313 @default.
• W2034196630 hasBestOaLocation W20341966301 @default.
• W2034196630 hasConcept C104317684 @default.
• W2034196630 hasConcept C126322002 @default.
• W2034196630 hasConcept C134018914 @default.
• W2034196630 hasConcept C180754005 @default.
• W2034196630 hasConcept C2777391703 @default.
• W2034196630 hasConcept C2779306644 @default.
• W2034196630 hasConcept C2780186808 @default.
• W2034196630 hasConcept C3018442814 @default.
• W2034196630 hasConcept C36823959 @default.
• W2034196630 hasConcept C54355233 @default.
• W2034196630 hasConcept C71924100 @default.
• W2034196630 hasConcept C86803240 @default.
• W2034196630 hasConceptScore W2034196630C104317684 @default.
• W2034196630 hasConceptScore W2034196630C126322002 @default.
• W2034196630 hasConceptScore W2034196630C134018914 @default.
• W2034196630 hasConceptScore W2034196630C180754005 @default.
• W2034196630 hasConceptScore W2034196630C2777391703 @default.
• W2034196630 hasConceptScore W2034196630C2779306644 @default.
• W2034196630 hasConceptScore W2034196630C2780186808 @default.
• W2034196630 hasConceptScore W2034196630C3018442814 @default.
• W2034196630 hasConceptScore W2034196630C36823959 @default.
• W2034196630 hasConceptScore W2034196630C54355233 @default.
• W2034196630 hasConceptScore W2034196630C71924100 @default.
• W2034196630 hasConceptScore W2034196630C86803240 @default.
• W2034196630 hasIssue "8" @default.
• W2034196630 hasLocation W20341966301 @default.
• W2034196630 hasLocation W20341966302 @default.
• W2034196630 hasLocation W20341966303 @default.
• W2034196630 hasOpenAccess W2034196630 @default.
• W2034196630 hasPrimaryLocation W20341966301 @default.
• W2034196630 hasRelatedWork W1998506244 @default.
• W2034196630 hasRelatedWork W2020998291 @default.
• W2034196630 hasRelatedWork W2022955668 @default.
• W2034196630 hasRelatedWork W2031854978 @default.
• W2034196630 hasRelatedWork W2055600249 @default.
• W2034196630 hasRelatedWork W2059374939 @default.
• W2034196630 hasRelatedWork W2065671703 @default.

• next