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- W2034197019 abstract "Astrocyte-enriched cultures prepared from the newborn rat cortex incorporated [3H]myo-inositol into intracellular free inositol and inositol lipid pools. Noradrenaline and carbachol stimulated the turnover of these pools resulting in an increased accumulation of intracellular [3H]inositol phosphates. The effects of noradrenaline and carbachol were dose-dependent and blocked by specific alpha 1-adrenergic and muscarinic cholinergic receptor antagonists, respectively. The increase in [3H]inositol phosphate accumulation caused by these receptor antagonists was virtually unchanged when cultures were incubated in Ca2+-free medium, but was abolished when EGTA was also present in the Ca2+-free medium. Cultures of meningeal fibroblasts, the major cell type contaminating the astrocyte cultures, also accumulated [3H]myo-inositol, but no increased accumulation of [3H]inositol phosphates was found in response to either noradrenaline or carbachol." @default.
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- W2034197019 date "1985-11-01" @default.
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- W2034197019 title "Activation of Muscarinic and of ?1-Adrenergic Receptors on Astrocytes Results in the Accumulation of Inositol Phosphates" @default.
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- W2034197019 doi "https://doi.org/10.1111/j.1471-4159.1985.tb07224.x" @default.
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