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- W2034197295 abstract "In our efforts to identify potent CRF1 antagonists with proper physicochemical properties, a series of 3-phenylpyrazolo[1,5-a]pyrimidines bearing polar groups, such as amino, hydroxyl, methoxy, sulfoxide, were designed and synthesized. Several positions of the core structure were identified, where a polar group was tolerated with slight reduction in receptor binding. NBI 30545 (18n) was found to have good binding affinity and potent antagonistic activity at the human CRF1 receptor. Moreover, this compound had proper lipophilicity (logD=2.78) and good solubility in water (>10 mg/mL), and exhibited good plasma and brain exposure when given orally." @default.
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- W2034197295 date "2008-08-01" @default.
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- W2034197295 title "P.2.d.020 Saredutant (SR48968), a NK2 receptor antagonist, blocks chronic stress-induced decrease in neurogenesis in Balb/c mice" @default.
- W2034197295 doi "https://doi.org/10.1016/s0924-977x(08)70502-9" @default.
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