FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034197887> ?p ?o ?g. }

• W2034197887 endingPage "962" @default.
• W2034197887 startingPage "919" @default.
• W2034197887 abstract "The quinone/semiquinone/hydroquinone triad (Q/SQ(*-)/H(2)Q) represents a class of compounds that has great importance in a wide range of biological processes. The half-cell reduction potentials of these redox couples in aqueous solutions at neutral pH, E degrees ', provide a window to understanding the thermodynamic and kinetic characteristics of this triad and their associated chemistry and biochemistry in vivo. Substituents on the quinone ring can significantly influence the electron density on the ring and thus modify E degrees' dramatically. E degrees' of the quinone governs the reaction of semiquinone with dioxygen to form superoxide. At near-neutral pH the pK(a)'s of the hydroquinone are outstanding indicators of the electron density in the aromatic ring of the members of these triads (electrophilicity) and thus are excellent tools to predict half-cell reduction potentials for both the one-electron and two-electron couples, which in turn allow estimates of rate constants for the reactions of these triads. For example, the higher the pK(a)'s of H(2)Q, the lower the reduction potentials and the higher the rate constants for the reaction of SQ(*-) with dioxygen to form superoxide. However, hydroquinone autoxidation is controlled by the concentration of di-ionized hydroquinone; thus, the lower the pK(a)'s the less stable H(2)Q to autoxidation. Catalysts, e.g., metals and quinone, can accelerate oxidation processes; by removing superoxide and increasing the rate of formation of quinone, superoxide dismutase can accelerate oxidation of hydroquinones and thereby increase the flux of hydrogen peroxide. The principal reactions of quinones are with nucleophiles via Michael addition, for example, with thiols and amines. The rate constants for these addition reactions are also related to E degrees'. Thus, pK(a)'s of a hydroquinone and E degrees ' are central to the chemistry of these triads." @default.
• W2034197887 created "2016-06-24" @default.
• W2034197887 creator A5077315942 @default.
• W2034197887 creator A5082072789 @default.
• W2034197887 date "2010-09-15" @default.
• W2034197887 modified "2023-09-30" @default.
• W2034197887 title "Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide" @default.
• W2034197887 cites W102568115 @default.
• W2034197887 cites W1499531920 @default.
• W2034197887 cites W1509435897 @default.
• W2034197887 cites W1520271781 @default.
• W2034197887 cites W1528070768 @default.
• W2034197887 cites W1560525055 @default.
• W2034197887 cites W1576822037 @default.
• W2034197887 cites W1589769838 @default.
• W2034197887 cites W1750690213 @default.
• W2034197887 cites W1781803186 @default.
• W2034197887 cites W1914842947 @default.
• W2034197887 cites W1966512729 @default.
• W2034197887 cites W1967977416 @default.
• W2034197887 cites W1969600052 @default.
• W2034197887 cites W1969628253 @default.
• W2034197887 cites W1969991575 @default.
• W2034197887 cites W1970000275 @default.
• W2034197887 cites W1971748722 @default.
• W2034197887 cites W1974425511 @default.
• W2034197887 cites W1974431142 @default.
• W2034197887 cites W1975942106 @default.
• W2034197887 cites W1976195740 @default.
• W2034197887 cites W1978470731 @default.
• W2034197887 cites W1979238357 @default.
• W2034197887 cites W1979424160 @default.
• W2034197887 cites W1979643802 @default.
• W2034197887 cites W1979857905 @default.
• W2034197887 cites W1979886021 @default.
• W2034197887 cites W1980088111 @default.
• W2034197887 cites W1985348295 @default.
• W2034197887 cites W1986286866 @default.
• W2034197887 cites W1987600115 @default.
• W2034197887 cites W1987633665 @default.
• W2034197887 cites W1991670774 @default.
• W2034197887 cites W1992437051 @default.
• W2034197887 cites W1992786087 @default.
• W2034197887 cites W1994496081 @default.
• W2034197887 cites W1995890978 @default.
• W2034197887 cites W1997225362 @default.
• W2034197887 cites W2001582935 @default.
• W2034197887 cites W2003296927 @default.
• W2034197887 cites W2003982180 @default.
• W2034197887 cites W2005118820 @default.
• W2034197887 cites W2005749652 @default.
• W2034197887 cites W2010808909 @default.
• W2034197887 cites W2011727704 @default.
• W2034197887 cites W2011871029 @default.
• W2034197887 cites W2013037193 @default.
• W2034197887 cites W2019539084 @default.
• W2034197887 cites W2019881589 @default.
• W2034197887 cites W2020214814 @default.
• W2034197887 cites W2024092039 @default.
• W2034197887 cites W2024668347 @default.
• W2034197887 cites W2024731313 @default.
• W2034197887 cites W2027043097 @default.
• W2034197887 cites W2029024582 @default.
• W2034197887 cites W2030505486 @default.
• W2034197887 cites W2031425666 @default.
• W2034197887 cites W2031568694 @default.
• W2034197887 cites W2032353647 @default.
• W2034197887 cites W2035426198 @default.
• W2034197887 cites W2035976372 @default.
• W2034197887 cites W2036885964 @default.
• W2034197887 cites W2037078657 @default.
• W2034197887 cites W2038217992 @default.
• W2034197887 cites W2040063499 @default.
• W2034197887 cites W2043675538 @default.
• W2034197887 cites W2051802937 @default.
• W2034197887 cites W2053295165 @default.
• W2034197887 cites W2054829241 @default.
• W2034197887 cites W2055829143 @default.
• W2034197887 cites W2057442686 @default.
• W2034197887 cites W2057937274 @default.
• W2034197887 cites W2059802515 @default.
• W2034197887 cites W2060013516 @default.
• W2034197887 cites W2061242359 @default.
• W2034197887 cites W2062685867 @default.
• W2034197887 cites W2064600250 @default.
• W2034197887 cites W2064814151 @default.
• W2034197887 cites W2068181456 @default.
• W2034197887 cites W2069593462 @default.
• W2034197887 cites W2071267404 @default.
• W2034197887 cites W2074067031 @default.
• W2034197887 cites W2076823356 @default.
• W2034197887 cites W2077069398 @default.
• W2034197887 cites W2078166953 @default.
• W2034197887 cites W2079548309 @default.
• W2034197887 cites W2079621700 @default.
• W2034197887 cites W2080229355 @default.
• W2034197887 cites W2080304693 @default.
• W2034197887 cites W2080668248 @default.

• next