Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034200280> ?p ?o ?g. }
- W2034200280 endingPage "547" @default.
- W2034200280 startingPage "519" @default.
- W2034200280 abstract "Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS) classification for 927 drugs, which include 30 active metabolites. Of the 897 parent drugs, 78.8% (707) are administered orally. Where the lowest measured solubility is found, this value is reported for 72.7% (513) of these orally administered drugs and a dose number is recorded. The measured values are reported for percent excreted unchanged in urine, LogP, and LogD 7.4 when available. For all 927 compounds, the in silico parameters for predicted Log solubility in water, calculated LogP, polar surface area, and the number of hydrogen bond acceptors and hydrogen bond donors for the active moiety are also provided, thereby allowing comparison analyses for both in silico and experimentally measured values. We discuss the potential use of BDDCS to estimate the disposition characteristics of novel chemicals (new molecular entities) in the early stages of drug discovery and development. Transporter effects in the intestine and the liver are not clinically relevant for BDDCS class 1 drugs, but potentially can have a high impact for class 2 (efflux in the gut, and efflux and uptake in the liver) and class 3 (uptake and efflux in both gut and liver) drugs. A combination of high dose and low solubility is likely to cause BDDCS class 4 to be underpopulated in terms of approved drugs (N = 53 compared with over 200 each in classes 1–3). The influence of several measured and in silico parameters in the process of BDDCS category assignment is discussed in detail." @default.
- W2034200280 created "2016-06-24" @default.
- W2034200280 creator A5047272417 @default.
- W2034200280 creator A5061685157 @default.
- W2034200280 creator A5075960682 @default.
- W2034200280 date "2011-08-05" @default.
- W2034200280 modified "2023-10-07" @default.
- W2034200280 title "BDDCS Applied to Over 900 Drugs" @default.
- W2034200280 cites W1498305210 @default.
- W2034200280 cites W1559072304 @default.
- W2034200280 cites W1965625101 @default.
- W2034200280 cites W1974574813 @default.
- W2034200280 cites W1978892904 @default.
- W2034200280 cites W1985989412 @default.
- W2034200280 cites W1991512646 @default.
- W2034200280 cites W1996783775 @default.
- W2034200280 cites W2000819024 @default.
- W2034200280 cites W2003556240 @default.
- W2034200280 cites W2006661934 @default.
- W2034200280 cites W2007052092 @default.
- W2034200280 cites W2007850344 @default.
- W2034200280 cites W2016425824 @default.
- W2034200280 cites W2028133542 @default.
- W2034200280 cites W2033454953 @default.
- W2034200280 cites W2041420541 @default.
- W2034200280 cites W2048384644 @default.
- W2034200280 cites W2060992818 @default.
- W2034200280 cites W2069506489 @default.
- W2034200280 cites W2070889577 @default.
- W2034200280 cites W2079600319 @default.
- W2034200280 cites W2082660639 @default.
- W2034200280 cites W2090138592 @default.
- W2034200280 cites W2091758060 @default.
- W2034200280 cites W2094750196 @default.
- W2034200280 cites W2096523918 @default.
- W2034200280 cites W2104075487 @default.
- W2034200280 cites W2111016992 @default.
- W2034200280 cites W2112722416 @default.
- W2034200280 cites W2115786648 @default.
- W2034200280 cites W2124775757 @default.
- W2034200280 cites W2131138924 @default.
- W2034200280 cites W2131626361 @default.
- W2034200280 cites W2134289054 @default.
- W2034200280 cites W2135732933 @default.
- W2034200280 cites W2136918221 @default.
- W2034200280 cites W2142400726 @default.
- W2034200280 cites W2154480514 @default.
- W2034200280 cites W2157970175 @default.
- W2034200280 cites W2163572677 @default.
- W2034200280 cites W2171654601 @default.
- W2034200280 cites W2341261432 @default.
- W2034200280 cites W82186612 @default.
- W2034200280 doi "https://doi.org/10.1208/s12248-011-9290-9" @default.
- W2034200280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3231854" @default.
- W2034200280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21818695" @default.
- W2034200280 hasPublicationYear "2011" @default.
- W2034200280 type Work @default.
- W2034200280 sameAs 2034200280 @default.
- W2034200280 citedByCount "513" @default.
- W2034200280 countsByYear W20342002802012 @default.
- W2034200280 countsByYear W20342002802013 @default.
- W2034200280 countsByYear W20342002802014 @default.
- W2034200280 countsByYear W20342002802015 @default.
- W2034200280 countsByYear W20342002802016 @default.
- W2034200280 countsByYear W20342002802017 @default.
- W2034200280 countsByYear W20342002802018 @default.
- W2034200280 countsByYear W20342002802019 @default.
- W2034200280 countsByYear W20342002802020 @default.
- W2034200280 countsByYear W20342002802021 @default.
- W2034200280 countsByYear W20342002802022 @default.
- W2034200280 countsByYear W20342002802023 @default.
- W2034200280 crossrefType "journal-article" @default.
- W2034200280 hasAuthorship W2034200280A5047272417 @default.
- W2034200280 hasAuthorship W2034200280A5061685157 @default.
- W2034200280 hasAuthorship W2034200280A5075960682 @default.
- W2034200280 hasBestOaLocation W20342002802 @default.
- W2034200280 hasConcept C104317684 @default.
- W2034200280 hasConcept C112705442 @default.
- W2034200280 hasConcept C155574463 @default.
- W2034200280 hasConcept C178790620 @default.
- W2034200280 hasConcept C185592680 @default.
- W2034200280 hasConcept C200082930 @default.
- W2034200280 hasConcept C207464780 @default.
- W2034200280 hasConcept C2775905019 @default.
- W2034200280 hasConcept C2780035454 @default.
- W2034200280 hasConcept C2781430271 @default.
- W2034200280 hasConcept C32909587 @default.
- W2034200280 hasConcept C55493867 @default.
- W2034200280 hasConcept C71924100 @default.
- W2034200280 hasConcept C98274493 @default.
- W2034200280 hasConceptScore W2034200280C104317684 @default.
- W2034200280 hasConceptScore W2034200280C112705442 @default.
- W2034200280 hasConceptScore W2034200280C155574463 @default.
- W2034200280 hasConceptScore W2034200280C178790620 @default.
- W2034200280 hasConceptScore W2034200280C185592680 @default.
- W2034200280 hasConceptScore W2034200280C200082930 @default.
- W2034200280 hasConceptScore W2034200280C207464780 @default.
- W2034200280 hasConceptScore W2034200280C2775905019 @default.