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• W2034200537 endingPage "464" @default.
• W2034200537 startingPage "457" @default.
• W2034200537 abstract "The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) subtypes and the levels and phosphorylation of the plasticity-associated protein GAP-43 were assayed in the hippocampus at varying times after training. We observed a rapid activation of hippocampal PKC (15 min through 24 h), with differential translocation of the PKC isotypes studied. At early times after CFC (15–90 min), PKCα and PKCγ translocated to the membrane, while PKCβII and PKCϵ moved more transiently (15 to 30 min) to the cytosol. These PKC isotypes returned to the membrane at later time points after CFC. Correlating with these changes in PKC translocation and activity, there was an early decrease in GAP-43 phosphorylation followed by a more sustained increase from 1.5-72 h. GAP-43 protein levels were also increased after 3 h, and these levels remained elevated for at least 72 h. These changes in PKC and GAP-43 were specific to the CFC trained animals and no changes were seen in animals exposed to the same stimuli in a non-associative fashion. Comparison of translocation of different PKC isotypes with the changes in GAP-43 phosphorylation suggested that PKCβII and PKCϵ may mediate both the early changes in the phosphorylation of this protein and the increases in GAP-43 expression at later times after CFC. Hippocampus 2002;12:457–464. © 2002 Wiley-Liss, Inc." @default.
• W2034200537 created "2016-06-24" @default.
• W2034200537 creator A5026184632 @default.
• W2034200537 creator A5041951804 @default.
• W2034200537 creator A5073356577 @default.
• W2034200537 creator A5089887663 @default.
• W2034200537 date "2002-01-01" @default.
• W2034200537 modified "2023-10-10" @default.
• W2034200537 title "Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm" @default.
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• W2034200537 doi "https://doi.org/10.1002/hipo.10015" @default.
• W2034200537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12201630" @default.
• W2034200537 hasPublicationYear "2002" @default.
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