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- W2034201098 abstract "Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein-protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-X(L), respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer." @default.
- W2034201098 created "2016-06-24" @default.
- W2034201098 creator A5014512900 @default.
- W2034201098 creator A5075936981 @default.
- W2034201098 date "2008-04-07" @default.
- W2034201098 modified "2023-10-17" @default.
- W2034201098 title "FOXOs, cancer and regulation of apoptosis" @default.
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- W2034201098 doi "https://doi.org/10.1038/onc.2008.24" @default.
- W2034201098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2819403" @default.
- W2034201098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18391973" @default.
- W2034201098 hasPublicationYear "2008" @default.
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