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• W2034201761 endingPage "1151" @default.
• W2034201761 startingPage "1137" @default.
• W2034201761 abstract "Telomeric DNA repeats are key features of chromosomes that allow the maintenance of integrity and stability in the telomeres. However, interstitial telomere sites (ITSs) can also be found along the chromosomes, especially near the centromere, where they may appear following chromosomal rearrangements like Robertsonian translocations. There is no defined role for ITSs, but they are linked to DNA damage-prone sites. We were interested in studying the structural organization of ITSs during meiosis, a kind of cell division in which programmed DNA damage events and noticeable chromatin reorganizations occur. Here we describe the presence of highly amplified ITSs in the pericentromeric region of Mongolian gerbil (Meriones unguiculatus) chromosomes. During meiosis, ITSs show a different chromatin conformation than DNA repeats at telomeres, appearing more extended and accumulating heterochromatin markers. Interestingly, ITSs also recruit the telomeric proteins RAP1 and TRF1, but in a stage-dependent manner, appearing mainly at late prophase I stages. We did not find a specific accumulation of DNA repair factors to the ITSs, such as γH2AX or RAD51 at these stages, but we could detect the presence of MLH1, a marker for reciprocal recombination. However, contrary to previous reports, we did not find a specific accumulation of crossovers at ITSs. Intriguingly, some centromeric regions of metacentric chromosomes may bind the nuclear envelope through the association to SUN1 protein, a feature usually performed by telomeres. Therefore, ITSs present a particular and dynamic chromatin configuration in meiosis, which could be involved in maintaining their genetic stability, but they additionally retain some features of distal telomeres, provided by their capability to associate to telomere-binding proteins." @default.
• W2034201761 created "2016-06-24" @default.
• W2034201761 creator A5019768972 @default.
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• W2034201761 date "2014-08-01" @default.
• W2034201761 modified "2023-10-16" @default.
• W2034201761 title "Chromatin Organization and Remodeling of Interstitial Telomeric Sites During Meiosis in the Mongolian Gerbil (<i>Meriones unguiculatus</i>)" @default.
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• W2034201761 doi "https://doi.org/10.1534/genetics.114.166421" @default.
• W2034201761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4125389" @default.
• W2034201761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24907260" @default.
• W2034201761 hasPublicationYear "2014" @default.
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