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- W2034202994 abstract "Submucosal glands of the tracheobronchial airways provide the important functions of secreting mucins, antimicrobial substances, and fluid. This review focuses on the ionic mechanism and regulation of gland fluid secretion and examines the possible role of gland dysfunction in the lethal disease cystic fibrosis (CF). The fluid component of gland secretion is driven by the active transepithelial secretion of both Cl(-) and HCO(3)(-) by serous cells. Gland fluid secretion is neurally regulated with acetylcholine, substance P, and vasoactive intestinal peptide (VIP) playing prominent roles. The cystic fibrosis transmembrane conductance regulator (CFTR) is present in the apical membrane of gland serous cells and mediates the VIP-induced component of liquid secretion whereas the muscarinic component of liquid secretion appears to be at least partially CFTR-independent. Loss of CFTR function, which occurs in CF disease, reduces the capacity of glands to secrete fluid but not mucins. The possible links between the loss of fluid secretion capability and the complex airway pathology of CF are discussed." @default.
- W2034202994 created "2016-06-24" @default.
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- W2034202994 date "2007-12-01" @default.
- W2034202994 modified "2023-10-09" @default.
- W2034202994 title "Fluid secretion by submucosal glands of the tracheobronchial airways" @default.
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- W2034202994 cites W1952965636 @default.
- W2034202994 cites W1969273529 @default.
- W2034202994 cites W1969697265 @default.
- W2034202994 cites W1971051736 @default.
- W2034202994 cites W1976881101 @default.
- W2034202994 cites W1983114544 @default.
- W2034202994 cites W1984413566 @default.
- W2034202994 cites W1984447869 @default.
- W2034202994 cites W1987894556 @default.
- W2034202994 cites W1988491749 @default.
- W2034202994 cites W1990637933 @default.
- W2034202994 cites W1999793793 @default.
- W2034202994 cites W2013306854 @default.
- W2034202994 cites W2016417321 @default.
- W2034202994 cites W2016910768 @default.
- W2034202994 cites W2020212141 @default.
- W2034202994 cites W2022634662 @default.
- W2034202994 cites W2026288936 @default.
- W2034202994 cites W2032482731 @default.
- W2034202994 cites W2039599894 @default.
- W2034202994 cites W2041706794 @default.
- W2034202994 cites W2045419222 @default.
- W2034202994 cites W2049914201 @default.
- W2034202994 cites W2050573110 @default.
- W2034202994 cites W2053672287 @default.
- W2034202994 cites W2063684531 @default.
- W2034202994 cites W2070967881 @default.
- W2034202994 cites W2074136802 @default.
- W2034202994 cites W2078078890 @default.
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- W2034202994 doi "https://doi.org/10.1016/j.resp.2007.06.017" @default.
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