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• W2034204409 abstract "The cardiac insulin-like growth factor 2 receptor (IGF-2R) can induce cardiomyocyte hypertrophy in a heterotrimeric G protein receptor-coupled manner involving αq (Gαq) or αs (Gαs). We have previously shown increased left ventricular weight and cardiac IGF-2 and IGF-2R gene expression in low-birth-weight (LBW) compared with average-birth-weight (ABW) lambs. Here, we have investigated the cardiac expression of IGF-2 gene variants, the degree of histone acetylation, and the abundance of proteins in the IGF-2R downstream signaling pathway in ABW and LBW lambs. Samples from the left ventricle of ABW and LBW lambs were collected at 21 days of age. There was increased phospho-CaMKII protein with decreased HDAC 4 abundance in the LBW compared with ABW lambs. There was increased GATA 4 and decreased phospho-troponin I abundance in LBW compared with ABW lambs, which are markers of pathological cardiac hypertrophy and impaired or reduced contractility, respectively. There was increased histone acetylation of H3K9 at IGF-2R promoter and IGF-2R intron 2 differentially methylated region in the LBW lamb. In conclusion, histone acetylation of IGF-2R may lead to increased IGF-2R mRNA expression and subsequently mediate Gαq signaling early in life via CaMKII, resulting in an increased risk of left ventricular hypertrophy and cardiovascular disease in adult life." @default.
• W2034204409 created "2016-06-24" @default.
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• W2034204409 date "2015-04-01" @default.
• W2034204409 modified "2023-10-16" @default.
• W2034204409 title "IGF-2R-G_αqsignaling and cardiac hypertrophy in the low-birth-weight lamb" @default.
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• W2034204409 doi "https://doi.org/10.1152/ajpregu.00346.2014" @default.
• W2034204409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4385999" @default.
• W2034204409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25632020" @default.
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