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- W2034205457 abstract "Alternative molecular mechanisms can be envisaged for the cellular repair of UV-damaged DNA. In the random collision model, DNA damage distributed throughout the genome is recognised and repaired by a process of random collision between DNA damage and repair enzymes. The other model assumes a processive mechanism, whereby DNA is scanned for damage by a repair complex moving steadily along its length. These two models give different predictions concerning the time course of repair. Random collision should result in a declining rate of repair with time as the concentration of lesions in the DNA falls; but the processive model predicts a constant rate of repair until scanning is complete. We have examined the time course of DNA repair in human fibroblasts given low (generally sublethal) doses of UV light. Using 3 distinct assays, we find no sign of a constant repair rate after 4 J/m2 or less, even when the first few hours after irradiation are examined. Thus DNA repair is likely to depend on random collision. The implications of this finding for the structural organisation of repair are discussed." @default.
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- W2034205457 date "1986-07-01" @default.
- W2034205457 modified "2023-09-26" @default.
- W2034205457 title "The time course of repair ultraviolet-induced DNA damage; implications for the structural organisation of repair" @default.
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- W2034205457 doi "https://doi.org/10.1016/0167-8817(86)90046-5" @default.
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