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- W2034206105 abstract "Whereas Kvβ2 subunits modulate potassium current properties carried by Kv1 channel complexes in heterologous systems, little is known about the contributions of Kvβ2 subunits to native potassium channel function. Using antisense approaches and in situ recordings from Xenopus embryo spinal cord neurons, we tested the in vivo roles of Kvβ2 subunits in modulation of voltage-dependent potassium current ( I Kv ). We focused on 1) two different populations of dorsal spinal neurons that express both Kvβ2 and Kv1 α-subunit genes and 2) the 24- and 48-h developmental period, during which I Kv undergoes developmental regulation. At both 24 and 48 h, antisense methods produced efficient knock-down of both Kvβ2 protein and I Kv . At both times, dominant negative suppression of Kv1 channels also eliminated I Kv , indicating that Kv1 channels require Kvβ2 subunits to function in dorsal spinal neurons. Even though Kv1 channels determined the I Kv values of both dorsal neuron types, comparisons of their I Kv properties revealed important differences at both developmental stages. The latter results support the notion that different Kv1 α-subunits and/or posttranslational modifications underlie the I Kv values of the two dorsal neuron types. Overall, the results demonstrate that Kvβ2 subunits function in vivo as obligatory subunits of Kv1 channels in at least two neuron types and two different developmental stages." @default.
- W2034206105 created "2016-06-24" @default.
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- W2034206105 date "2008-10-01" @default.
- W2034206105 modified "2023-09-27" @default.
- W2034206105 title "Kv1 Potassium Channel Complexes In Vivo Require Kvβ2 Subunits in Dorsal Spinal Neurons" @default.
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- W2034206105 doi "https://doi.org/10.1152/jn.90667.2008" @default.
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