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• W2034207821 abstract "Sprague-Dawley rats were subjected to a moderate level (2.2 atm) of traumatic brain injury (TBI) using fluid percussion. Injured animals were allowed post-trauma survival periods of 5 min, 3 and 24 h. Regional glutamate receptor subtype binding was assessed with quantitative autoradiography in each group forN-methyl-d-aspartate (NMDA), quisqualate and kainate receptor subpopulations at approximately the −3.8 bregma level and compared to a sham control group. [3H]glutamate binding to the NMDA receptor was significantly (P < 0.05) decreased at 3 h post-TBI in the hippocampal CA1 stratum radiatum, the molecular layers of the dentate gyri and the outer (layers 1–3) and inner (layers 5 and 6) overlying neocortex. NMDA receptor binding was significantly reduced in layers 5 and 6 of the neocortex at all post-trauma survival times but no further differences were seen in the hippocampi. No significant changes were observed with [3H]AMPA binding to quisqualate receptors and [3H]KA binding was significantly reduced only in layers 5 and 6 of the neocortex at 24 h after TBI. These data further confirm the pathological involvemnt of the NMDA receptor complex in brain regions selectively vulnerable to moderate levels of TBI in this model." @default.
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• W2034207821 date "1990-08-01" @default.
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• W2034207821 title "Excitatory amino acid receptor subtype binding following traumatic brain injury" @default.
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• W2034207821 doi "https://doi.org/10.1016/0006-8993(90)90254-9" @default.
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