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- W2034208532 abstract "The relaxation responses of aortic rings of rats fed either normal rat feed, 8% salt diet, 8% salt+2.5% Ca diet or 2.5% Ca diet for 6–8 weeks has been investigated. The mean arterial pressure of salt loaded rats (148.63±8.54 mmHg) was higher (P<0.05) than those of control (108.36±7.81 mmHg), salt-loaded Ca-fed (101.62±7.38) and Ca fed (98.54±8.72) rats. The maximum KCl-induced relaxation of the aortic rings was least (55.5±3.5%, P<0.05) in salt loaded rats when compared to the maximum KCl-induced relaxation of control (70.76±3.65%), salt+Ca fed (73.12±3.46%) and Ca fed (79.3±3.68%) rats. Salt loading attenuated the maximum relaxation to CaCl2 (P<0.05) when compared to the maximum relaxation responses of control rats, salt+Ca fed and Ca fed rats. The Mg-induced relaxation was lower (P<0.05) in salt loaded rats than any other group. Increasing the extracellular fluid calcium concentration to 2.61 and 5.1 mmol l−1 significantly (P<0.05) increased the relaxation responses to MgSO4 in aortic rings from all the groups. The result of this study indicates that salt-loading caused significant increase in the blood pressure of the rats and also reduced the relaxation responses of the aortic rings to KCl, MgSO4 and CaCl2 which suggest altered Na+,K+-ATPase activity and resistance of the vascular smooth muscle membrane to calcium-induced membrane stabilization. These defects were reversed by dietary calcium supplement." @default.
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- W2034208532 date "1998-01-01" @default.
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- W2034208532 title "Relaxation responses of aortic rings from salt-loaded high calcium fed rats to potassium chloride, calcium chloride and magnesium sulphate" @default.
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- W2034208532 doi "https://doi.org/10.1016/s0928-4680(97)10004-9" @default.
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