FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034209850> ?p ?o ?g. }

• W2034209850 endingPage "339" @default.
• W2034209850 startingPage "333" @default.
• W2034209850 abstract "Three known coumarins have been isolated from Citrus hystrix DC as inhibitors of both lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-induced nitric oxide (NO) generation in RAW 264.7 cells. The inhibitory activity of bergamottin (IC50 = 14 μM) was comparable to that of N-(iminoethyl)-l-ornithine (l-NIO) (IC50 = 7.9 μM), whereas oxypeucedanin and 5-[(6‘,7‘-dihydroxy-3‘,7‘-dimethyl-2-octenyl)oxy]psoralen, structurally different from bergamottin only in their side-chain moieties, were notably less active. Using 21 coumarins, we structurally classified various types of coumarins into groups A−C: (A) bearing an isoprenyl (IP) or a geranyl (GR) group, highly active; (B) bearing an IP group cyclized to a coumarin ring, moderately active; (C) bearing an IP group modified with hydroxyl group(s) and/or having other functional groups except for the IP, completely inactive. Cellular uptake studies suggested that coumarins in group C are inactive because of poor permeability to the cell membrane. Keywords: Citrus hystrix DC; psoralen; coumarin; nitric oxide; RAW 264.7 cells; structure−activity relationships" @default.
• W2034209850 created "2016-06-24" @default.
• W2034209850 creator A5011191571 @default.
• W2034209850 creator A5035851945 @default.
• W2034209850 creator A5038089230 @default.
• W2034209850 creator A5042875484 @default.
• W2034209850 creator A5047410208 @default.
• W2034209850 creator A5049348918 @default.
• W2034209850 creator A5054832481 @default.
• W2034209850 creator A5057163448 @default.
• W2034209850 creator A5064834249 @default.
• W2034209850 creator A5090752457 @default.
• W2034209850 date "1998-12-10" @default.
• W2034209850 modified "2023-10-01" @default.
• W2034209850 title "Identification of Coumarins from the Fruit of <i>Citrus hystrix</i> DC as Inhibitors of Nitric Oxide Generation in Mouse Macrophage RAW 264.7 Cells" @default.
• W2034209850 cites W1965425404 @default.
• W2034209850 cites W1968747857 @default.
• W2034209850 cites W1969192989 @default.
• W2034209850 cites W1970314789 @default.
• W2034209850 cites W1972169413 @default.
• W2034209850 cites W1973018387 @default.
• W2034209850 cites W1990802251 @default.
• W2034209850 cites W1991209235 @default.
• W2034209850 cites W1999382806 @default.
• W2034209850 cites W2000507365 @default.
• W2034209850 cites W2011220321 @default.
• W2034209850 cites W2011812683 @default.
• W2034209850 cites W2017039268 @default.
• W2034209850 cites W2036134769 @default.
• W2034209850 cites W2049805652 @default.
• W2034209850 cites W2052950894 @default.
• W2034209850 cites W2094050302 @default.
• W2034209850 cites W2107515713 @default.
• W2034209850 cites W2119088209 @default.
• W2034209850 doi "https://doi.org/10.1021/jf980523e" @default.
• W2034209850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10563895" @default.
• W2034209850 hasPublicationYear "1998" @default.
• W2034209850 type Work @default.
• W2034209850 sameAs 2034209850 @default.
• W2034209850 citedByCount "54" @default.
• W2034209850 countsByYear W20342098502012 @default.
• W2034209850 countsByYear W20342098502013 @default.
• W2034209850 countsByYear W20342098502014 @default.
• W2034209850 countsByYear W20342098502015 @default.
• W2034209850 countsByYear W20342098502016 @default.
• W2034209850 countsByYear W20342098502017 @default.
• W2034209850 countsByYear W20342098502018 @default.
• W2034209850 countsByYear W20342098502019 @default.
• W2034209850 countsByYear W20342098502020 @default.
• W2034209850 countsByYear W20342098502021 @default.
• W2034209850 countsByYear W20342098502022 @default.
• W2034209850 countsByYear W20342098502023 @default.
• W2034209850 crossrefType "journal-article" @default.
• W2034209850 hasAuthorship W2034209850A5011191571 @default.
• W2034209850 hasAuthorship W2034209850A5035851945 @default.
• W2034209850 hasAuthorship W2034209850A5038089230 @default.
• W2034209850 hasAuthorship W2034209850A5042875484 @default.
• W2034209850 hasAuthorship W2034209850A5047410208 @default.
• W2034209850 hasAuthorship W2034209850A5049348918 @default.
• W2034209850 hasAuthorship W2034209850A5054832481 @default.
• W2034209850 hasAuthorship W2034209850A5057163448 @default.
• W2034209850 hasAuthorship W2034209850A5064834249 @default.
• W2034209850 hasAuthorship W2034209850A5090752457 @default.
• W2034209850 hasConcept C178790620 @default.
• W2034209850 hasConcept C185592680 @default.
• W2034209850 hasConcept C202751555 @default.
• W2034209850 hasConcept C2777752497 @default.
• W2034209850 hasConcept C2781110370 @default.
• W2034209850 hasConcept C2781338262 @default.
• W2034209850 hasConcept C519581460 @default.
• W2034209850 hasConcept C552990157 @default.
• W2034209850 hasConcept C55493867 @default.
• W2034209850 hasConcept C71240020 @default.
• W2034209850 hasConceptScore W2034209850C178790620 @default.
• W2034209850 hasConceptScore W2034209850C185592680 @default.
• W2034209850 hasConceptScore W2034209850C202751555 @default.
• W2034209850 hasConceptScore W2034209850C2777752497 @default.
• W2034209850 hasConceptScore W2034209850C2781110370 @default.
• W2034209850 hasConceptScore W2034209850C2781338262 @default.
• W2034209850 hasConceptScore W2034209850C519581460 @default.
• W2034209850 hasConceptScore W2034209850C552990157 @default.
• W2034209850 hasConceptScore W2034209850C55493867 @default.
• W2034209850 hasConceptScore W2034209850C71240020 @default.
• W2034209850 hasIssue "1" @default.
• W2034209850 hasLocation W20342098501 @default.
• W2034209850 hasLocation W20342098502 @default.
• W2034209850 hasOpenAccess W2034209850 @default.
• W2034209850 hasPrimaryLocation W20342098501 @default.
• W2034209850 hasRelatedWork W2034209850 @default.
• W2034209850 hasRelatedWork W2072273640 @default.
• W2034209850 hasRelatedWork W2076312474 @default.
• W2034209850 hasRelatedWork W2084267068 @default.
• W2034209850 hasRelatedWork W2087222627 @default.
• W2034209850 hasRelatedWork W2290005648 @default.
• W2034209850 hasRelatedWork W2390825481 @default.
• W2034209850 hasRelatedWork W2401212985 @default.
• W2034209850 hasRelatedWork W2949948670 @default.
• W2034209850 hasRelatedWork W2950284420 @default.

• next