Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034210044> ?p ?o ?g. }
- W2034210044 endingPage "892" @default.
- W2034210044 startingPage "878" @default.
- W2034210044 abstract "The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use a chemical genetics screen to identify direct substrates of AMPK in human cells. We find that AMPK phosphorylates 28 previously unidentified substrates, several of which are involved in mitosis and cytokinesis. We identify the residues phosphorylated by AMPK in vivo in several substrates, including protein phosphatase 1 regulatory subunit 12C (PPP1R12C) and p21-activated protein kinase (PAK2). AMPK-induced phosphorylation is necessary for PPP1R12C interaction with 14-3-3 and phosphorylation of myosin regulatory light chain. Both AMPK activity and PPP1R12C phosphorylation are increased in mitotic cells and are important for mitosis completion. These findings suggest that AMPK coordinates nutrient status with mitosis completion, which may be critical for the organism's response to low nutrients during development, or in adult stem and cancer cells." @default.
- W2034210044 created "2016-06-24" @default.
- W2034210044 creator A5002358767 @default.
- W2034210044 creator A5005646080 @default.
- W2034210044 creator A5012147587 @default.
- W2034210044 creator A5025847390 @default.
- W2034210044 creator A5040169949 @default.
- W2034210044 creator A5056691147 @default.
- W2034210044 creator A5060801206 @default.
- W2034210044 creator A5063610356 @default.
- W2034210044 creator A5068708143 @default.
- W2034210044 creator A5071160136 @default.
- W2034210044 creator A5073615852 @default.
- W2034210044 creator A5079376363 @default.
- W2034210044 creator A5079793809 @default.
- W2034210044 creator A5084981510 @default.
- W2034210044 creator A5088357328 @default.
- W2034210044 date "2011-12-01" @default.
- W2034210044 modified "2023-10-17" @default.
- W2034210044 title "Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis" @default.
- W2034210044 cites W1486970791 @default.
- W2034210044 cites W1503573288 @default.
- W2034210044 cites W1559050064 @default.
- W2034210044 cites W1790807154 @default.
- W2034210044 cites W1965085059 @default.
- W2034210044 cites W1967251674 @default.
- W2034210044 cites W1968881729 @default.
- W2034210044 cites W1969236463 @default.
- W2034210044 cites W1970205234 @default.
- W2034210044 cites W1973622869 @default.
- W2034210044 cites W1977621221 @default.
- W2034210044 cites W1984994493 @default.
- W2034210044 cites W1987966101 @default.
- W2034210044 cites W2001568034 @default.
- W2034210044 cites W2005892444 @default.
- W2034210044 cites W2010238890 @default.
- W2034210044 cites W2011464522 @default.
- W2034210044 cites W2014885180 @default.
- W2034210044 cites W2015222879 @default.
- W2034210044 cites W2022630818 @default.
- W2034210044 cites W2024196905 @default.
- W2034210044 cites W2028786309 @default.
- W2034210044 cites W2030202463 @default.
- W2034210044 cites W2038578974 @default.
- W2034210044 cites W2044874695 @default.
- W2034210044 cites W2045033550 @default.
- W2034210044 cites W2045771446 @default.
- W2034210044 cites W2046822015 @default.
- W2034210044 cites W2054076116 @default.
- W2034210044 cites W2065850832 @default.
- W2034210044 cites W2067979493 @default.
- W2034210044 cites W2070224555 @default.
- W2034210044 cites W2074894911 @default.
- W2034210044 cites W2079622198 @default.
- W2034210044 cites W2081008671 @default.
- W2034210044 cites W2081920342 @default.
- W2034210044 cites W2083731894 @default.
- W2034210044 cites W2084314276 @default.
- W2034210044 cites W2085558309 @default.
- W2034210044 cites W2085567056 @default.
- W2034210044 cites W2087840427 @default.
- W2034210044 cites W2106823075 @default.
- W2034210044 cites W2107034836 @default.
- W2034210044 cites W2108357729 @default.
- W2034210044 cites W2112668580 @default.
- W2034210044 cites W2115168068 @default.
- W2034210044 cites W2117275311 @default.
- W2034210044 cites W2117629868 @default.
- W2034210044 cites W2125130090 @default.
- W2034210044 cites W2130016073 @default.
- W2034210044 cites W2137218119 @default.
- W2034210044 cites W2138226825 @default.
- W2034210044 cites W2138416557 @default.
- W2034210044 cites W2159856430 @default.
- W2034210044 cites W2161422385 @default.
- W2034210044 cites W4238757102 @default.
- W2034210044 doi "https://doi.org/10.1016/j.molcel.2011.11.005" @default.
- W2034210044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246132" @default.
- W2034210044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22137581" @default.
- W2034210044 hasPublicationYear "2011" @default.
- W2034210044 type Work @default.
- W2034210044 sameAs 2034210044 @default.
- W2034210044 citedByCount "217" @default.
- W2034210044 countsByYear W20342100442012 @default.
- W2034210044 countsByYear W20342100442013 @default.
- W2034210044 countsByYear W20342100442014 @default.
- W2034210044 countsByYear W20342100442015 @default.
- W2034210044 countsByYear W20342100442016 @default.
- W2034210044 countsByYear W20342100442017 @default.
- W2034210044 countsByYear W20342100442018 @default.
- W2034210044 countsByYear W20342100442019 @default.
- W2034210044 countsByYear W20342100442020 @default.
- W2034210044 countsByYear W20342100442021 @default.
- W2034210044 countsByYear W20342100442022 @default.
- W2034210044 countsByYear W20342100442023 @default.
- W2034210044 crossrefType "journal-article" @default.
- W2034210044 hasAuthorship W2034210044A5002358767 @default.
- W2034210044 hasAuthorship W2034210044A5005646080 @default.