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- W2034210355 abstract "In this report the use of surface-linkage to expand the potential experimental and therapeutic applications of single chain antibody (scFv) constructs is reviewed. A strategy for the generation and functional characterization of surface-linked scFvs that bind selectively to the T-cell proteins CD3ϵ, CD28, and CD152 (CTLA-4) is described in detail. Experimental examples are provided of the use of these constructs to study the positive and negative regulation of T-cell activation and to manipulate the in vivo immunogenicity of tumor cells. In addition, a novel system for Simultaneous T-cell Activation and Retroviral Transduction (START) is described in which retroviral packaging cells are rendered mitogenic for T lymphocytes by combined expression of surface-linked scFvs. Finally, the use of random mutagenesis and yeast surface display to increase the affinity and functional efficacy of scFv constructs is demonstrated." @default.
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- W2034210355 date "2001-02-01" @default.
- W2034210355 modified "2023-09-25" @default.
- W2034210355 title "Development and applications of surface-linked single chain antibodies against T-cell antigens" @default.
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- W2034210355 doi "https://doi.org/10.1016/s0022-1759(00)00344-6" @default.
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