FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034211073> ?p ?o ?g. }

• W2034211073 abstract "Currently different Toll-like receptor (TLR) agonists are tested in humans for their ability to enhance the efficacy of specific immunotherapy (SIT). Recent clinical data suggest that this may be achieved by increasing allergen-specific Th1 responses. However, it is not clear which TLR agonist is best suited to be used in combination with SIT. We tested the ability of five TLR agonists, LTA, poly(I:C), LPS, R848, and CpG-ODN, activating TLR2, 3, 4, 7, and 9, to induce allergen-specific Th1 and suppress allergen-specific Th2 responses in a preclinical setting. Mice were immunized by intraperitoneal injection of ovalbumin (OVA)/Al(OH)3 together with different doses (0.0025, 0.025, 0.25, and 2.5 mg/kg) of agonists followed by two OVA aerosol challenges. The results of these experiments showed, that the suppression of allergen-specific Th2 responses and the induction of Th1 responses dependedon the dose and the agonists used. All TLR agonists increased allergen-specific IgG2a, and with the exception of poly(I:C), reduced allergen-specific IgE levels in the serum. Allergic cutaneous anaphylaxis was also suppressed in mice when LPS or CpG was given together with OVA/alum. The strongest Th1 responses were induced by CpG and poly(I:C), characterized by the presence of IFN-g in the BAL and the highest OVA-specific IgG2a levels in the serum. This study suggests that the TLR9 agonist CpG-ODN and TLR4 agonist LPS have the strongest suppressive effects on the development of aller-gen-specific Th2 responses in mice and CpG-ODN induces the strongest allergen-specific Th1 responses. Therefore these two TLR agonists may be good candidates to combine with allergen in novel SIT formulations in humans." @default.
• W2034211073 created "2016-06-24" @default.
• W2034211073 creator A5035755383 @default.
• W2034211073 creator A5067100777 @default.
• W2034211073 creator A5082447090 @default.
• W2034211073 creator A5091613480 @default.
• W2034211073 date "2012-01-01" @default.
• W2034211073 modified "2023-09-28" @default.
• W2034211073 title "Adjuvant effects of different TLR agonists on the induction of allergen-specific Th2 responses" @default.
• W2034211073 cites W1487011840 @default.
• W2034211073 cites W1873495658 @default.
• W2034211073 cites W1966279732 @default.
• W2034211073 cites W1968428761 @default.
• W2034211073 cites W1969251366 @default.
• W2034211073 cites W1983675236 @default.
• W2034211073 cites W1984708466 @default.
• W2034211073 cites W2020559881 @default.
• W2034211073 cites W2037841532 @default.
• W2034211073 cites W2038835351 @default.
• W2034211073 cites W2046148198 @default.
• W2034211073 cites W2052122855 @default.
• W2034211073 cites W2064352339 @default.
• W2034211073 cites W2084480726 @default.
• W2034211073 cites W2092194474 @default.
• W2034211073 cites W2113082911 @default.
• W2034211073 cites W2121827176 @default.
• W2034211073 cites W2131722921 @default.
• W2034211073 cites W2141211628 @default.
• W2034211073 cites W2155774990 @default.
• W2034211073 cites W2165126386 @default.
• W2034211073 cites W2312829609 @default.
• W2034211073 cites W2397048678 @default.
• W2034211073 doi "https://doi.org/10.4236/oji.2012.21003" @default.
• W2034211073 hasPublicationYear "2012" @default.
• W2034211073 type Work @default.
• W2034211073 sameAs 2034211073 @default.
• W2034211073 citedByCount "2" @default.
• W2034211073 countsByYear W20342110732016 @default.
• W2034211073 crossrefType "journal-article" @default.
• W2034211073 hasAuthorship W2034211073A5035755383 @default.
• W2034211073 hasAuthorship W2034211073A5067100777 @default.
• W2034211073 hasAuthorship W2034211073A5082447090 @default.
• W2034211073 hasAuthorship W2034211073A5091613480 @default.
• W2034211073 hasBestOaLocation W20342110731 @default.
• W2034211073 hasConcept C104317684 @default.
• W2034211073 hasConcept C126322002 @default.
• W2034211073 hasConcept C141105273 @default.
• W2034211073 hasConcept C150194340 @default.
• W2034211073 hasConcept C159654299 @default.
• W2034211073 hasConcept C170493617 @default.
• W2034211073 hasConcept C185592680 @default.
• W2034211073 hasConcept C190727270 @default.
• W2034211073 hasConcept C203014093 @default.
• W2034211073 hasConcept C207480886 @default.
• W2034211073 hasConcept C2776070231 @default.
• W2034211073 hasConcept C2776946954 @default.
• W2034211073 hasConcept C2777863537 @default.
• W2034211073 hasConcept C2778938600 @default.
• W2034211073 hasConcept C2779138994 @default.
• W2034211073 hasConcept C2780510475 @default.
• W2034211073 hasConcept C2781236682 @default.
• W2034211073 hasConcept C55493867 @default.
• W2034211073 hasConcept C71924100 @default.
• W2034211073 hasConcept C8891405 @default.
• W2034211073 hasConcept C98274493 @default.
• W2034211073 hasConceptScore W2034211073C104317684 @default.
• W2034211073 hasConceptScore W2034211073C126322002 @default.
• W2034211073 hasConceptScore W2034211073C141105273 @default.
• W2034211073 hasConceptScore W2034211073C150194340 @default.
• W2034211073 hasConceptScore W2034211073C159654299 @default.
• W2034211073 hasConceptScore W2034211073C170493617 @default.
• W2034211073 hasConceptScore W2034211073C185592680 @default.
• W2034211073 hasConceptScore W2034211073C190727270 @default.
• W2034211073 hasConceptScore W2034211073C203014093 @default.
• W2034211073 hasConceptScore W2034211073C207480886 @default.
• W2034211073 hasConceptScore W2034211073C2776070231 @default.
• W2034211073 hasConceptScore W2034211073C2776946954 @default.
• W2034211073 hasConceptScore W2034211073C2777863537 @default.
• W2034211073 hasConceptScore W2034211073C2778938600 @default.
• W2034211073 hasConceptScore W2034211073C2779138994 @default.
• W2034211073 hasConceptScore W2034211073C2780510475 @default.
• W2034211073 hasConceptScore W2034211073C2781236682 @default.
• W2034211073 hasConceptScore W2034211073C55493867 @default.
• W2034211073 hasConceptScore W2034211073C71924100 @default.
• W2034211073 hasConceptScore W2034211073C8891405 @default.
• W2034211073 hasConceptScore W2034211073C98274493 @default.
• W2034211073 hasLocation W20342110731 @default.
• W2034211073 hasOpenAccess W2034211073 @default.
• W2034211073 hasPrimaryLocation W20342110731 @default.
• W2034211073 hasRelatedWork W1976697576 @default.
• W2034211073 hasRelatedWork W1984608824 @default.
• W2034211073 hasRelatedWork W1994773210 @default.
• W2034211073 hasRelatedWork W1997503261 @default.
• W2034211073 hasRelatedWork W2005757619 @default.
• W2034211073 hasRelatedWork W2034345733 @default.
• W2034211073 hasRelatedWork W2049983341 @default.
• W2034211073 hasRelatedWork W2093399505 @default.
• W2034211073 hasRelatedWork W2094362908 @default.
• W2034211073 hasRelatedWork W2117839825 @default.
• W2034211073 hasRelatedWork W2123467599 @default.

• next