Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034211100> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2034211100 endingPage "142" @default.
- W2034211100 startingPage "137" @default.
- W2034211100 abstract "The aim was to investigate the long-term evolution of circulating growth hormone antibodies (GH-AB) during and after treatment with methionyl-recombinant human growth hormone (met-rhGH).The investigation was performed on serum samples of 46 growth hormone deficient children, treated for at least 12 months with met-rhGH. Twenty patients had never been treated with hGH (previously untreated patients, Group I). Twenty-six subjects were previously treated with pituitary extracted hGH (treated patients, Group II).Serum levels of GH-AB were measured by radioimmunoassay using charcoal precipitation of free ligand.Fifteen patients (75%) of Group I and three patients (12%) of Group II developed GH-AB. In 15 GH-AB positive patients the antibodies became detectable during the first year of treatment with met-rhGH. In three patients, however, the GH-AB appeared during the second year. Once present, the GH-AB remained detectable throughout the period of treatment with met-rhGH. In six patients in whom treatment with met-rhGH was stopped, GH-AB levels decreased rapidly. In nine patients in whom treatment with met-rhGH was changed to rhGH, the levels of GH-AB decreased and ultimately became undetectable. In two patients GH-AB remained present during administration of rhGH. No effect of GH-AB on the growth-promoting effect of met-rhGH could be documented, either during the first or during the second year of treatment.This study confirms the high immunogenicity of met-rhGH, especially in patients not treated earlier with hGH. Once present, the GH-AB remain detectable throughout the period of treatment with met-rhGH. After stopping met-rhGH treatment or changing to rhGH the GH-AB disappear rapidly in most patients. No effect of GH-AB on the growth-promoting effect of rhGH could be documented." @default.
- W2034211100 created "2016-06-24" @default.
- W2034211100 creator A5003437398 @default.
- W2034211100 creator A5064274383 @default.
- W2034211100 creator A5064355733 @default.
- W2034211100 date "1993-02-01" @default.
- W2034211100 modified "2023-10-18" @default.
- W2034211100 title "Five-year follow-up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone" @default.
- W2034211100 cites W1983649348 @default.
- W2034211100 cites W1994416898 @default.
- W2034211100 cites W2010334259 @default.
- W2034211100 cites W2033927889 @default.
- W2034211100 cites W2037001982 @default.
- W2034211100 cites W2037883880 @default.
- W2034211100 cites W2043807987 @default.
- W2034211100 cites W2058635810 @default.
- W2034211100 cites W2063233433 @default.
- W2034211100 cites W2089064845 @default.
- W2034211100 cites W2089728262 @default.
- W2034211100 cites W2096871076 @default.
- W2034211100 cites W2117600730 @default.
- W2034211100 cites W2161578575 @default.
- W2034211100 cites W2409380009 @default.
- W2034211100 cites W4303002977 @default.
- W2034211100 doi "https://doi.org/10.1111/j.1365-2265.1993.tb00985.x" @default.
- W2034211100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8435894" @default.
- W2034211100 hasPublicationYear "1993" @default.
- W2034211100 type Work @default.
- W2034211100 sameAs 2034211100 @default.
- W2034211100 citedByCount "47" @default.
- W2034211100 countsByYear W20342111002012 @default.
- W2034211100 countsByYear W20342111002013 @default.
- W2034211100 countsByYear W20342111002014 @default.
- W2034211100 countsByYear W20342111002015 @default.
- W2034211100 countsByYear W20342111002016 @default.
- W2034211100 countsByYear W20342111002017 @default.
- W2034211100 countsByYear W20342111002019 @default.
- W2034211100 countsByYear W20342111002021 @default.
- W2034211100 countsByYear W20342111002023 @default.
- W2034211100 crossrefType "journal-article" @default.
- W2034211100 hasAuthorship W2034211100A5003437398 @default.
- W2034211100 hasAuthorship W2034211100A5064274383 @default.
- W2034211100 hasAuthorship W2034211100A5064355733 @default.
- W2034211100 hasConcept C104317684 @default.
- W2034211100 hasConcept C126322002 @default.
- W2034211100 hasConcept C134018914 @default.
- W2034211100 hasConcept C159654299 @default.
- W2034211100 hasConcept C176685330 @default.
- W2034211100 hasConcept C203014093 @default.
- W2034211100 hasConcept C2778135454 @default.
- W2034211100 hasConcept C2910954651 @default.
- W2034211100 hasConcept C2984496839 @default.
- W2034211100 hasConcept C2994100043 @default.
- W2034211100 hasConcept C40767141 @default.
- W2034211100 hasConcept C55493867 @default.
- W2034211100 hasConcept C71315377 @default.
- W2034211100 hasConcept C71924100 @default.
- W2034211100 hasConcept C86803240 @default.
- W2034211100 hasConceptScore W2034211100C104317684 @default.
- W2034211100 hasConceptScore W2034211100C126322002 @default.
- W2034211100 hasConceptScore W2034211100C134018914 @default.
- W2034211100 hasConceptScore W2034211100C159654299 @default.
- W2034211100 hasConceptScore W2034211100C176685330 @default.
- W2034211100 hasConceptScore W2034211100C203014093 @default.
- W2034211100 hasConceptScore W2034211100C2778135454 @default.
- W2034211100 hasConceptScore W2034211100C2910954651 @default.
- W2034211100 hasConceptScore W2034211100C2984496839 @default.
- W2034211100 hasConceptScore W2034211100C2994100043 @default.
- W2034211100 hasConceptScore W2034211100C40767141 @default.
- W2034211100 hasConceptScore W2034211100C55493867 @default.
- W2034211100 hasConceptScore W2034211100C71315377 @default.
- W2034211100 hasConceptScore W2034211100C71924100 @default.
- W2034211100 hasConceptScore W2034211100C86803240 @default.
- W2034211100 hasIssue "2" @default.
- W2034211100 hasLocation W20342111001 @default.
- W2034211100 hasLocation W20342111002 @default.
- W2034211100 hasOpenAccess W2034211100 @default.
- W2034211100 hasPrimaryLocation W20342111001 @default.
- W2034211100 hasRelatedWork W1980166143 @default.
- W2034211100 hasRelatedWork W2014432291 @default.
- W2034211100 hasRelatedWork W2014717352 @default.
- W2034211100 hasRelatedWork W2019415346 @default.
- W2034211100 hasRelatedWork W2024757249 @default.
- W2034211100 hasRelatedWork W2072014172 @default.
- W2034211100 hasRelatedWork W2079613337 @default.
- W2034211100 hasRelatedWork W2113910008 @default.
- W2034211100 hasRelatedWork W2127124347 @default.
- W2034211100 hasRelatedWork W4242480643 @default.
- W2034211100 hasVolume "38" @default.
- W2034211100 isParatext "false" @default.
- W2034211100 isRetracted "false" @default.
- W2034211100 magId "2034211100" @default.
- W2034211100 workType "article" @default.