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• W2034211305 abstract "HIV‐1 gp120/gp160 is known to disturb the activity of p56 lck , protein kinase C (PKC) and Ca 2+ homeostasis in T lymphocytes. We found that gp160 decreases the Kv1.3 current of Jurkat E6.1 cells probably by increasing the PKC‐dependent phosphorylation of Kv channel protein after 5 days. This decrease is dose‐dependent. In contrast, gp160 did not decrease the Kv1.3 current of the JCaM1.6 cell line, a p56 lck ‐defective Jurkat cell line. This shows that p56 lck was at the beginning of the events which induced the Kv1.3 current decrease. As a consequence of this decrease, Jurkat E6.1 cells were depolarized and exhibited a volume increase." @default.
• W2034211305 created "2016-06-24" @default.
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• W2034211305 date "1999-01-29" @default.
• W2034211305 modified "2023-10-18" @default.
• W2034211305 title "HIV‐1 gp160 decreases the K⁺ voltage‐gated current from Jurkat E6.1 T cells by up‐phosphorylation" @default.
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• W2034211305 doi "https://doi.org/10.1016/s0014-5793(98)01691-3" @default.
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