Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034215563> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034215563 endingPage "312a" @default.
- W2034215563 startingPage "312a" @default.
- W2034215563 abstract "We have investigated Ca2+-sensitivity changes in cardiac and skeletal muscle due to mutations or phosphorylation of troponin I (TnI) using the in vitro motility assay.In normal heart, TnI phosphorylation alters myofibrillar Ca2+-sensitivity and increases the speed of Ca2+-dissociation (lusitropic effect). When end-stage heart failure samples with a reduced level of phosphorylation were looked at, the average Ca2+-sensitivity change was x2.6±0.24.Eight dilated cardiomyopathy (DCM) mutations have been looked at in all components of the thin filament (Actin E361G, TnT R141W and ΔK210, TnI K36Q, TnC G159D and Tm E40K, E54K and D230N). Although they all have differing effects on Ca2+-sensitivity (some increased it and some decreased it) the average Ca2+-sensitivity change was x2.0±0.16.The actin E99K hypertrophic cardiomyopathy (HCM) mutation causes an increase in Ca2+-sensitivity of x2.5 but a literature search looking at 21 other HCM mutations in every sarcomeric protein has found an average Ca2+-sensitivity change of x1.8±0.13.A wide range of skeletal myopathies were looked at which either caused a gain of function (TPM2 ΔK49, ΔE139, ACTA1 K326N and TPM3 ΔK7) or loss of function (TPM2 E117K, R91P and TPM3 A4V, L100M and R167C). The mean changes of Ca2+-sensitivity were x1.8±0.3 and x2.7±0.4 respectively.It is remarkable that mutations causing a range of different striated muscle myopathies have such a similar and limited effect on myofilament Ca2+-sensitivity and that phosphorylation of troponin I regulates Ca2+-sensitivity over the same range. We have found in DCM and HCM that Ca2+-sensitivity is uncoupled from the level of TnI phosphorylation and tends to the Ca2+-sensitivity characteristic of phosphorylated wild-type muscle at all phosphorylation levels. It is tempting to speculate that the 2-fold change represents a transition between two activation states of the thin filament." @default.
- W2034215563 created "2016-06-24" @default.
- W2034215563 creator A5004233445 @default.
- W2034215563 creator A5014377678 @default.
- W2034215563 creator A5082630247 @default.
- W2034215563 creator A5090645838 @default.
- W2034215563 date "2013-01-01" @default.
- W2034215563 modified "2023-09-29" @default.
- W2034215563 title "There is a Limit to the Changes in Myofilament Ca2+-Sensitivity due to Myopathies" @default.
- W2034215563 doi "https://doi.org/10.1016/j.bpj.2012.11.1731" @default.
- W2034215563 hasPublicationYear "2013" @default.
- W2034215563 type Work @default.
- W2034215563 sameAs 2034215563 @default.
- W2034215563 citedByCount "0" @default.
- W2034215563 crossrefType "journal-article" @default.
- W2034215563 hasAuthorship W2034215563A5004233445 @default.
- W2034215563 hasAuthorship W2034215563A5014377678 @default.
- W2034215563 hasAuthorship W2034215563A5082630247 @default.
- W2034215563 hasAuthorship W2034215563A5090645838 @default.
- W2034215563 hasBestOaLocation W20342155631 @default.
- W2034215563 hasConcept C115725540 @default.
- W2034215563 hasConcept C11960822 @default.
- W2034215563 hasConcept C12554922 @default.
- W2034215563 hasConcept C125705527 @default.
- W2034215563 hasConcept C126322002 @default.
- W2034215563 hasConcept C134018914 @default.
- W2034215563 hasConcept C164705383 @default.
- W2034215563 hasConcept C174054327 @default.
- W2034215563 hasConcept C185592680 @default.
- W2034215563 hasConcept C2779959927 @default.
- W2034215563 hasConcept C36036425 @default.
- W2034215563 hasConcept C500558357 @default.
- W2034215563 hasConcept C55493867 @default.
- W2034215563 hasConcept C71924100 @default.
- W2034215563 hasConcept C7301908 @default.
- W2034215563 hasConcept C86803240 @default.
- W2034215563 hasConceptScore W2034215563C115725540 @default.
- W2034215563 hasConceptScore W2034215563C11960822 @default.
- W2034215563 hasConceptScore W2034215563C12554922 @default.
- W2034215563 hasConceptScore W2034215563C125705527 @default.
- W2034215563 hasConceptScore W2034215563C126322002 @default.
- W2034215563 hasConceptScore W2034215563C134018914 @default.
- W2034215563 hasConceptScore W2034215563C164705383 @default.
- W2034215563 hasConceptScore W2034215563C174054327 @default.
- W2034215563 hasConceptScore W2034215563C185592680 @default.
- W2034215563 hasConceptScore W2034215563C2779959927 @default.
- W2034215563 hasConceptScore W2034215563C36036425 @default.
- W2034215563 hasConceptScore W2034215563C500558357 @default.
- W2034215563 hasConceptScore W2034215563C55493867 @default.
- W2034215563 hasConceptScore W2034215563C71924100 @default.
- W2034215563 hasConceptScore W2034215563C7301908 @default.
- W2034215563 hasConceptScore W2034215563C86803240 @default.
- W2034215563 hasIssue "2" @default.
- W2034215563 hasLocation W20342155631 @default.
- W2034215563 hasOpenAccess W2034215563 @default.
- W2034215563 hasPrimaryLocation W20342155631 @default.
- W2034215563 hasRelatedWork W1724553668 @default.
- W2034215563 hasRelatedWork W1987313263 @default.
- W2034215563 hasRelatedWork W1998868419 @default.
- W2034215563 hasRelatedWork W2005100675 @default.
- W2034215563 hasRelatedWork W2007284588 @default.
- W2034215563 hasRelatedWork W2007694213 @default.
- W2034215563 hasRelatedWork W2009953198 @default.
- W2034215563 hasRelatedWork W2011680094 @default.
- W2034215563 hasRelatedWork W2025759932 @default.
- W2034215563 hasRelatedWork W2037805212 @default.
- W2034215563 hasRelatedWork W2055790484 @default.
- W2034215563 hasRelatedWork W2065998364 @default.
- W2034215563 hasRelatedWork W2069639279 @default.
- W2034215563 hasRelatedWork W2070844936 @default.
- W2034215563 hasRelatedWork W2074693639 @default.
- W2034215563 hasRelatedWork W2076438593 @default.
- W2034215563 hasRelatedWork W2084317332 @default.
- W2034215563 hasRelatedWork W2090442001 @default.
- W2034215563 hasRelatedWork W2141706511 @default.
- W2034215563 hasRelatedWork W2507137242 @default.
- W2034215563 hasVolume "104" @default.
- W2034215563 isParatext "false" @default.
- W2034215563 isRetracted "false" @default.
- W2034215563 magId "2034215563" @default.
- W2034215563 workType "article" @default.