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- W2034220620 abstract "BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention." @default.
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- W2034220620 date "2005-02-01" @default.
- W2034220620 modified "2023-09-30" @default.
- W2034220620 title "BAG-1: a multi-functional pro-survival molecule" @default.
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- W2034220620 doi "https://doi.org/10.1016/j.biocel.2004.03.016" @default.
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