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• W2034221415 abstract "Nitric oxide (NO) is formed by a class of NO synthases (NOS), which convert arginine into citrulline. A decreasedin vivoNO availability can be the result of an increased NO inactivation or a decreased NO production. The latter can be assessed by measurement of isotopic enrichment of plasma citrulline during infusion of isotopically labeled arginine. The potential of high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) to determine enrichments of [15N2]arginine and [15N]citrulline in plasma during infusion of [15N2]arginine in humans was investigated. Two types of MS instruments were evaluated: a sector-type mass spectrometer equipped with a frit fast-atom bombardment (FAB) interface and a quadrupole instrument with electrospray ionization (ESI). FAB–MS appeared to be unsuitable for determination of isotope ratios, because background ions influenced the observed isotope ratio in an unpredictable way. In combination with either off- or on-line reversed-phase HPLC, ESI–MS proved to be a more reliable technique. However, the amount of material that is introduced in the mass spectrometer is critical and should be carefully controlled. During infusion of [15N2]arginine in 14 healthy subjects, a mean arginine-to-citrulline conversion rate of 0.22 ± 0.07 (SD) μmol.kg−1.h−1was found. In 4 subjects who received an intravenous infusion with the NOS antagonistl-NMMA, the conversion rate decreased from 0.30 ± 0.14 to 0.10 ± 0.06 μmol.kg−1.h−1. It is concluded that ESI–MS in combination with HPLC can be successfully applied for determination of arginine and citrulline enrichments in plasma, thus providing a useful tool for assessment ofin vivoNO production." @default.
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• W2034221415 date "1998-03-01" @default.
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• W2034221415 title "Assessment of Nitric Oxide Production by Measurement of [15N]Citrulline Enrichment in Human Plasma Using High-Performance Liquid Chromatography–Mass Spectrometry" @default.
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