FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034222321> ?p ?o ?g. }

• W2034222321 endingPage "46" @default.
• W2034222321 startingPage "41" @default.
• W2034222321 abstract "Eukaryotic initiation factor 2Bε (eIF2Bε) plays a critical role in the initiation of mRNA translation and its expression and guanine nucleotide exchange activity are major determinants of the rate of protein synthesis. In this work we provide evidence that the catalytic epsilon subunit of eIF2B is subject to ubiquitination and proteasome-mediated degradation. Lysates of C2C12 myoblasts treated with proteasome inhibitor were subjected to sequential immunoprecipitations for eIF2Bε followed by ubiquitin. Tandem mass spectrometry (LC–MS/MS) analysis of immunoprecipitated proteins resulted in the identification of five peptides containing ubiquitin (diglycine) modifications on eIF2Bε. The specific lysine residues containing the ubiquitin modifications were localized as Lys-56, Lys-98, Lys-136, Lys-212 and Lys-500 (corresponding to the rat protein sequence). In addition three novel phosphorylation sites were identified including Ser-22, Ser-125, and Thr-317. Moreover, peptides corresponding to the amino acid sequence of the E3 ligase NEDD4 were also detected in the LC–MS/MS analysis, and an interaction between endogenous eIF2Bε with NEDD4 was confirmed by co-immunoprecipitation." @default.
• W2034222321 created "2016-06-24" @default.
• W2034222321 creator A5005861452 @default.
• W2034222321 creator A5054423139 @default.
• W2034222321 creator A5059381245 @default.
• W2034222321 creator A5060108946 @default.
• W2034222321 date "2013-06-01" @default.
• W2034222321 modified "2023-10-18" @default.
• W2034222321 title "Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon" @default.
• W2034222321 cites W121954709 @default.
• W2034222321 cites W2001274114 @default.
• W2034222321 cites W2001505809 @default.
• W2034222321 cites W2001699397 @default.
• W2034222321 cites W2003204068 @default.
• W2034222321 cites W2011152648 @default.
• W2034222321 cites W2012917547 @default.
• W2034222321 cites W2015709967 @default.
• W2034222321 cites W2020265195 @default.
• W2034222321 cites W2028446721 @default.
• W2034222321 cites W2031599457 @default.
• W2034222321 cites W2038980978 @default.
• W2034222321 cites W2048195083 @default.
• W2034222321 cites W2048263228 @default.
• W2034222321 cites W2064872601 @default.
• W2034222321 cites W2066363580 @default.
• W2034222321 cites W2080182587 @default.
• W2034222321 cites W2080553628 @default.
• W2034222321 cites W2080848778 @default.
• W2034222321 cites W2081281632 @default.
• W2034222321 cites W2095675683 @default.
• W2034222321 cites W2101090646 @default.
• W2034222321 cites W2105249930 @default.
• W2034222321 cites W2105378957 @default.
• W2034222321 cites W2116839423 @default.
• W2034222321 cites W2128551987 @default.
• W2034222321 cites W2145786566 @default.
• W2034222321 cites W2152075974 @default.
• W2034222321 cites W2167836014 @default.
• W2034222321 cites W2297513371 @default.
• W2034222321 doi "https://doi.org/10.1016/j.bbrc.2013.05.053" @default.
• W2034222321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3744827" @default.
• W2034222321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23707720" @default.
• W2034222321 hasPublicationYear "2013" @default.
• W2034222321 type Work @default.
• W2034222321 sameAs 2034222321 @default.
• W2034222321 citedByCount "4" @default.
• W2034222321 countsByYear W20342223212016 @default.
• W2034222321 countsByYear W20342223212017 @default.
• W2034222321 countsByYear W20342223212018 @default.
• W2034222321 countsByYear W20342223212023 @default.
• W2034222321 crossrefType "journal-article" @default.
• W2034222321 hasAuthorship W2034222321A5005861452 @default.
• W2034222321 hasAuthorship W2034222321A5054423139 @default.
• W2034222321 hasAuthorship W2034222321A5059381245 @default.
• W2034222321 hasAuthorship W2034222321A5060108946 @default.
• W2034222321 hasBestOaLocation W20342223212 @default.
• W2034222321 hasConcept C104292427 @default.
• W2034222321 hasConcept C104317684 @default.
• W2034222321 hasConcept C105580179 @default.
• W2034222321 hasConcept C11960822 @default.
• W2034222321 hasConcept C126619667 @default.
• W2034222321 hasConcept C134459356 @default.
• W2034222321 hasConcept C149364088 @default.
• W2034222321 hasConcept C153911025 @default.
• W2034222321 hasConcept C175114707 @default.
• W2034222321 hasConcept C181199279 @default.
• W2034222321 hasConcept C185592680 @default.
• W2034222321 hasConcept C207332259 @default.
• W2034222321 hasConcept C25602115 @default.
• W2034222321 hasConcept C27740335 @default.
• W2034222321 hasConcept C2776016237 @default.
• W2034222321 hasConcept C4718897 @default.
• W2034222321 hasConcept C515207424 @default.
• W2034222321 hasConcept C55493867 @default.
• W2034222321 hasConcept C71829478 @default.
• W2034222321 hasConcept C86803240 @default.
• W2034222321 hasConcept C93734116 @default.
• W2034222321 hasConcept C95444343 @default.
• W2034222321 hasConcept C97154109 @default.
• W2034222321 hasConceptScore W2034222321C104292427 @default.
• W2034222321 hasConceptScore W2034222321C104317684 @default.
• W2034222321 hasConceptScore W2034222321C105580179 @default.
• W2034222321 hasConceptScore W2034222321C11960822 @default.
• W2034222321 hasConceptScore W2034222321C126619667 @default.
• W2034222321 hasConceptScore W2034222321C134459356 @default.
• W2034222321 hasConceptScore W2034222321C149364088 @default.
• W2034222321 hasConceptScore W2034222321C153911025 @default.
• W2034222321 hasConceptScore W2034222321C175114707 @default.
• W2034222321 hasConceptScore W2034222321C181199279 @default.
• W2034222321 hasConceptScore W2034222321C185592680 @default.
• W2034222321 hasConceptScore W2034222321C207332259 @default.
• W2034222321 hasConceptScore W2034222321C25602115 @default.
• W2034222321 hasConceptScore W2034222321C27740335 @default.
• W2034222321 hasConceptScore W2034222321C2776016237 @default.
• W2034222321 hasConceptScore W2034222321C4718897 @default.
• W2034222321 hasConceptScore W2034222321C515207424 @default.
• W2034222321 hasConceptScore W2034222321C55493867 @default.
• W2034222321 hasConceptScore W2034222321C71829478 @default.

• next