Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034223419> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2034223419 endingPage "478" @default.
- W2034223419 startingPage "467" @default.
- W2034223419 abstract "The effects of various doses of the converting enzyme inhibitor captopril injected into the lateral brain ventricle (i.c.v.) and intravenously (i.v.) on blood pressure (BP) and on converting enzyme activity were tested in stroke prone conscious spontaneously hypertensive rats (SHR-sp) and in normotensive Wistar Kyoto rats (WKY). Injection of 500 micrograms captopril i.c.v. produced a marked biphasic BP effect in SHR-sp, an initial increase followed by a long-lasting decrease. Only the initial BP increase was observed in WKY. The pressor responses to i.c.v. angiotensin I (ANG I) were completely blocked after i.c.v. captopril injection and this effect lasted for 24 h. The pressor responses to i.v. ANG I were also inhibited immediately after 500 micrograms captopril i.c.v. and gradually returned to control values within 5 h. Intravenous injections of 500 micrograms captopril almost completely inhibited the pressor responses to i.v. ANG I; they caused a moderate BP decrease in SHR-sp and had no significant BP effects in WKY. In SHR-sp, 5 micrograms captopril i.c.v. caused a reduction of BP with a concomitant inhibition of the pressor effects of i.c.v. ANG I. Both effects lasted about 30 min. The pressor responses to i.v. ANG I were not inhibited. In WKY, 5 micrograms captopril i.c.v. had no effect on BP. It is concluded that captopril can reduce BP by action on the brain without peripheral inhibition of converting enzymes. Following high doses injected i.c.v., the inhibitor leaks into the periphery but this cannot explain the marked hypotensive effect in SHR-sp." @default.
- W2034223419 created "2016-06-24" @default.
- W2034223419 creator A5008231286 @default.
- W2034223419 creator A5020333616 @default.
- W2034223419 creator A5052836637 @default.
- W2034223419 creator A5067539737 @default.
- W2034223419 date "1981-04-01" @default.
- W2034223419 modified "2023-09-23" @default.
- W2034223419 title "Brain converting enzyme inhibition: A possible mechanism for the antihypertensive action of captopril in spontaneously hypertensive rats" @default.
- W2034223419 cites W150938153 @default.
- W2034223419 cites W1966748845 @default.
- W2034223419 cites W1975005022 @default.
- W2034223419 cites W1982440318 @default.
- W2034223419 cites W2001955470 @default.
- W2034223419 cites W2008441006 @default.
- W2034223419 cites W2009711601 @default.
- W2034223419 cites W2033651040 @default.
- W2034223419 cites W2033859347 @default.
- W2034223419 cites W2067827164 @default.
- W2034223419 cites W2076030580 @default.
- W2034223419 cites W2093352678 @default.
- W2034223419 cites W2131390816 @default.
- W2034223419 cites W2142851189 @default.
- W2034223419 cites W2186883299 @default.
- W2034223419 cites W2319361024 @default.
- W2034223419 cites W2403434455 @default.
- W2034223419 cites W2423092490 @default.
- W2034223419 doi "https://doi.org/10.1016/0014-2999(81)90358-7" @default.
- W2034223419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6263638" @default.
- W2034223419 hasPublicationYear "1981" @default.
- W2034223419 type Work @default.
- W2034223419 sameAs 2034223419 @default.
- W2034223419 citedByCount "134" @default.
- W2034223419 countsByYear W20342234192012 @default.
- W2034223419 countsByYear W20342234192023 @default.
- W2034223419 crossrefType "journal-article" @default.
- W2034223419 hasAuthorship W2034223419A5008231286 @default.
- W2034223419 hasAuthorship W2034223419A5020333616 @default.
- W2034223419 hasAuthorship W2034223419A5052836637 @default.
- W2034223419 hasAuthorship W2034223419A5067539737 @default.
- W2034223419 hasConcept C126322002 @default.
- W2034223419 hasConcept C134018914 @default.
- W2034223419 hasConcept C181199279 @default.
- W2034223419 hasConcept C185592680 @default.
- W2034223419 hasConcept C198710026 @default.
- W2034223419 hasConcept C202751555 @default.
- W2034223419 hasConcept C27016395 @default.
- W2034223419 hasConcept C2776120743 @default.
- W2034223419 hasConcept C2776980637 @default.
- W2034223419 hasConcept C2778086073 @default.
- W2034223419 hasConcept C2779479957 @default.
- W2034223419 hasConcept C2908929049 @default.
- W2034223419 hasConcept C55493867 @default.
- W2034223419 hasConcept C71924100 @default.
- W2034223419 hasConcept C84393581 @default.
- W2034223419 hasConceptScore W2034223419C126322002 @default.
- W2034223419 hasConceptScore W2034223419C134018914 @default.
- W2034223419 hasConceptScore W2034223419C181199279 @default.
- W2034223419 hasConceptScore W2034223419C185592680 @default.
- W2034223419 hasConceptScore W2034223419C198710026 @default.
- W2034223419 hasConceptScore W2034223419C202751555 @default.
- W2034223419 hasConceptScore W2034223419C27016395 @default.
- W2034223419 hasConceptScore W2034223419C2776120743 @default.
- W2034223419 hasConceptScore W2034223419C2776980637 @default.
- W2034223419 hasConceptScore W2034223419C2778086073 @default.
- W2034223419 hasConceptScore W2034223419C2779479957 @default.
- W2034223419 hasConceptScore W2034223419C2908929049 @default.
- W2034223419 hasConceptScore W2034223419C55493867 @default.
- W2034223419 hasConceptScore W2034223419C71924100 @default.
- W2034223419 hasConceptScore W2034223419C84393581 @default.
- W2034223419 hasIssue "4" @default.
- W2034223419 hasLocation W20342234191 @default.
- W2034223419 hasLocation W20342234192 @default.
- W2034223419 hasOpenAccess W2034223419 @default.
- W2034223419 hasPrimaryLocation W20342234191 @default.
- W2034223419 hasRelatedWork W1995452552 @default.
- W2034223419 hasRelatedWork W2002602770 @default.
- W2034223419 hasRelatedWork W2016647631 @default.
- W2034223419 hasRelatedWork W2053149407 @default.
- W2034223419 hasRelatedWork W2070506935 @default.
- W2034223419 hasRelatedWork W2118552094 @default.
- W2034223419 hasRelatedWork W2126797993 @default.
- W2034223419 hasRelatedWork W2399247991 @default.
- W2034223419 hasRelatedWork W2402165612 @default.
- W2034223419 hasRelatedWork W2468687581 @default.
- W2034223419 hasVolume "70" @default.
- W2034223419 isParatext "false" @default.
- W2034223419 isRetracted "false" @default.
- W2034223419 magId "2034223419" @default.
- W2034223419 workType "article" @default.