Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034223448> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2034223448 endingPage "106" @default.
- W2034223448 startingPage "101" @default.
- W2034223448 abstract "To determine the feasibility of the micronuclei procedure for cytogenetic studies, a comparatively weak chromosome breaking agent, trimethylphosphate (TMP) and the potent alkylating agent, triethylenemelamine (TEM) were evaluated. The procedure followed was that of Matter and Schmid with the following modifications: (a) direct flushing of bone marrow with 0.2 ml calf fetal serum. (b) air drying slides for a period of only I h, and (c) the use of pH 6.0 phosphate buffer to dilute both Wright and Giemsa stains. With this technique a dose response curve was generated for both TMP and TEM, using mice as the experimental animal. With TMP, a doubling over background was found when a concentration of 0.5 g/kg per day for five days was administered. To establish a statistically significant doubling dose over the control, a minimum of five animals must be used with 2000 polychromatic cells being analyzed per animal. Of the two antischistosomal agents tested, hycanthone yielded an increase of 20-fold in the number of micronuclei over control at 40 mg/kg administered i.p. for five days, while with niridazole no increase in micronuclei at several concentrations tested both by single and multiple injection was found. The results obtained with these compounds compare favorably with what has been reported for the standard in vivo metaphase analysis." @default.
- W2034223448 created "2016-06-24" @default.
- W2034223448 creator A5066738152 @default.
- W2034223448 creator A5074438447 @default.
- W2034223448 creator A5076255208 @default.
- W2034223448 date "1975-04-01" @default.
- W2034223448 modified "2023-09-29" @default.
- W2034223448 title "An evaluation of the micronuclei test using triethylenemelamine, trimethylphosphate, hycanthone and niridazole" @default.
- W2034223448 cites W2002798549 @default.
- W2034223448 cites W2022957206 @default.
- W2034223448 cites W2046844160 @default.
- W2034223448 cites W2078696797 @default.
- W2034223448 cites W4234906101 @default.
- W2034223448 doi "https://doi.org/10.1016/0027-5107(75)90319-x" @default.
- W2034223448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1095914" @default.
- W2034223448 hasPublicationYear "1975" @default.
- W2034223448 type Work @default.
- W2034223448 sameAs 2034223448 @default.
- W2034223448 citedByCount "33" @default.
- W2034223448 countsByYear W20342234482012 @default.
- W2034223448 countsByYear W20342234482013 @default.
- W2034223448 countsByYear W20342234482014 @default.
- W2034223448 countsByYear W20342234482017 @default.
- W2034223448 countsByYear W20342234482018 @default.
- W2034223448 crossrefType "journal-article" @default.
- W2034223448 hasAuthorship W2034223448A5066738152 @default.
- W2034223448 hasAuthorship W2034223448A5074438447 @default.
- W2034223448 hasAuthorship W2034223448A5076255208 @default.
- W2034223448 hasConcept C104317684 @default.
- W2034223448 hasConcept C150903083 @default.
- W2034223448 hasConcept C154488023 @default.
- W2034223448 hasConcept C16685009 @default.
- W2034223448 hasConcept C178790620 @default.
- W2034223448 hasConcept C185592680 @default.
- W2034223448 hasConcept C203014093 @default.
- W2034223448 hasConcept C207001950 @default.
- W2034223448 hasConcept C2778959862 @default.
- W2034223448 hasConcept C2780007613 @default.
- W2034223448 hasConcept C29730261 @default.
- W2034223448 hasConcept C3019361144 @default.
- W2034223448 hasConcept C30481170 @default.
- W2034223448 hasConcept C33070731 @default.
- W2034223448 hasConcept C36681516 @default.
- W2034223448 hasConcept C45080847 @default.
- W2034223448 hasConcept C54355233 @default.
- W2034223448 hasConcept C55493867 @default.
- W2034223448 hasConcept C556039675 @default.
- W2034223448 hasConcept C70278784 @default.
- W2034223448 hasConcept C71924100 @default.
- W2034223448 hasConcept C86803240 @default.
- W2034223448 hasConceptScore W2034223448C104317684 @default.
- W2034223448 hasConceptScore W2034223448C150903083 @default.
- W2034223448 hasConceptScore W2034223448C154488023 @default.
- W2034223448 hasConceptScore W2034223448C16685009 @default.
- W2034223448 hasConceptScore W2034223448C178790620 @default.
- W2034223448 hasConceptScore W2034223448C185592680 @default.
- W2034223448 hasConceptScore W2034223448C203014093 @default.
- W2034223448 hasConceptScore W2034223448C207001950 @default.
- W2034223448 hasConceptScore W2034223448C2778959862 @default.
- W2034223448 hasConceptScore W2034223448C2780007613 @default.
- W2034223448 hasConceptScore W2034223448C29730261 @default.
- W2034223448 hasConceptScore W2034223448C3019361144 @default.
- W2034223448 hasConceptScore W2034223448C30481170 @default.
- W2034223448 hasConceptScore W2034223448C33070731 @default.
- W2034223448 hasConceptScore W2034223448C36681516 @default.
- W2034223448 hasConceptScore W2034223448C45080847 @default.
- W2034223448 hasConceptScore W2034223448C54355233 @default.
- W2034223448 hasConceptScore W2034223448C55493867 @default.
- W2034223448 hasConceptScore W2034223448C556039675 @default.
- W2034223448 hasConceptScore W2034223448C70278784 @default.
- W2034223448 hasConceptScore W2034223448C71924100 @default.
- W2034223448 hasConceptScore W2034223448C86803240 @default.
- W2034223448 hasIssue "1" @default.
- W2034223448 hasLocation W20342234481 @default.
- W2034223448 hasLocation W20342234482 @default.
- W2034223448 hasOpenAccess W2034223448 @default.
- W2034223448 hasPrimaryLocation W20342234481 @default.
- W2034223448 hasRelatedWork W2028804678 @default.
- W2034223448 hasRelatedWork W2039246310 @default.
- W2034223448 hasRelatedWork W2074547115 @default.
- W2034223448 hasRelatedWork W2125613508 @default.
- W2034223448 hasRelatedWork W2262652941 @default.
- W2034223448 hasRelatedWork W2368547367 @default.
- W2034223448 hasRelatedWork W2388289712 @default.
- W2034223448 hasRelatedWork W3207677898 @default.
- W2034223448 hasRelatedWork W4281985629 @default.
- W2034223448 hasRelatedWork W2189516150 @default.
- W2034223448 hasVolume "28" @default.
- W2034223448 isParatext "false" @default.
- W2034223448 isRetracted "false" @default.
- W2034223448 magId "2034223448" @default.
- W2034223448 workType "article" @default.