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• W2034224142 endingPage "219" @default.
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• W2034224142 abstract "There is a well-described association between infantile epilepsy and pervasive cognitive and behavioral deficits, including a high incidence of autism spectrum disorders. Despite the robustness of the relationship between early-life seizures and the development of autism, the pathophysiological mechanism by which this occurs has not been explored. As a result of increasing evidence that autism is a disorder of brain connectivity we hypothesized that early-life seizures would interrupt normal brain connectivity during brain maturation and result in an autistic phenotype. Normal rat pups underwent recurrent flurothyl-induced seizures from postnatal (P)days 5-14 and then tested, along with controls, for developmental alterations of development brain oscillatory activity from P18-P25. Specifically we wished to understand how normal changes in rhythmicity in and between brain regions change as a function of age and if this rhythmicity is altered or interrupted by early life seizures. In rat pups with early-life seizures, field recordings from dorsal and ventral hippocampus and prefrontal cortex demonstrated marked increase in coherence as well as a decrease in voltage correlation at all bandwidths compared to controls while there were minimal differences in total power and relative power spectral densities. Rats with early-life seizures had resulting impairment in the sociability and social novelty tests but demonstrated no evidence of increased activity or generalized anxiety as measured in the open field. In addition, rats with early-life seizures had lower seizure thresholds than controls, indicating long-standing alterations in the excitatory/inhibition balance. Bumetanide, a pharmacological agent that blocks the activity of NKCC1 and induces a significant shift of ECl toward more hyperpolarized values, administration at the time of the seizures precluded the subsequent abnormalities in coherence and voltage correlation and resulted in normal sociability and seizure threshold. Taken together these findings indicate that early-life seizures alter the development of oscillations and result in autistic-like behaviors. The altered communication between these brain regions could reflect the physiological underpinnings underlying social cognitive deficits seen in autism spectrum disorders." @default.
• W2034224142 created "2016-06-24" @default.
• W2034224142 creator A5015764264 @default.
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• W2034224142 creator A5061193174 @default.
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• W2034224142 date "2015-05-01" @default.
• W2034224142 modified "2023-10-14" @default.
• W2034224142 title "Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide" @default.
• W2034224142 cites W1603307924 @default.
• W2034224142 cites W1763727641 @default.
• W2034224142 cites W1801117657 @default.
• W2034224142 cites W1893459668 @default.
• W2034224142 cites W1957625529 @default.
• W2034224142 cites W1965183327 @default.
• W2034224142 cites W1966611184 @default.
• W2034224142 cites W1974169328 @default.
• W2034224142 cites W1981646265 @default.
• W2034224142 cites W1982508962 @default.
• W2034224142 cites W1987490682 @default.
• W2034224142 cites W1996764508 @default.
• W2034224142 cites W1997714374 @default.
• W2034224142 cites W1998877040 @default.
• W2034224142 cites W1999692166 @default.
• W2034224142 cites W2007430976 @default.
• W2034224142 cites W2008357008 @default.
• W2034224142 cites W2012272871 @default.
• W2034224142 cites W2013632767 @default.
• W2034224142 cites W2014310721 @default.
• W2034224142 cites W2014344384 @default.
• W2034224142 cites W2014535119 @default.
• W2034224142 cites W2016411894 @default.
• W2034224142 cites W2017046741 @default.
• W2034224142 cites W2018931488 @default.
• W2034224142 cites W2020549903 @default.
• W2034224142 cites W2022567100 @default.
• W2034224142 cites W2029291577 @default.
• W2034224142 cites W2029591740 @default.
• W2034224142 cites W2033021653 @default.
• W2034224142 cites W2036550958 @default.
• W2034224142 cites W2039031619 @default.
• W2034224142 cites W2039499702 @default.
• W2034224142 cites W2040149530 @default.
• W2034224142 cites W2041527603 @default.
• W2034224142 cites W2045096194 @default.
• W2034224142 cites W2046183844 @default.
• W2034224142 cites W2046593593 @default.
• W2034224142 cites W2047838025 @default.
• W2034224142 cites W2050708294 @default.
• W2034224142 cites W2054086319 @default.
• W2034224142 cites W2054875209 @default.
• W2034224142 cites W2062377220 @default.
• W2034224142 cites W2065738753 @default.
• W2034224142 cites W2076394931 @default.
• W2034224142 cites W2076415769 @default.
• W2034224142 cites W2077804523 @default.
• W2034224142 cites W2078226190 @default.
• W2034224142 cites W2078662546 @default.
• W2034224142 cites W2081331893 @default.
• W2034224142 cites W2082025223 @default.
• W2034224142 cites W2082752208 @default.
• W2034224142 cites W2082813494 @default.
• W2034224142 cites W2084291081 @default.
• W2034224142 cites W2087622391 @default.
• W2034224142 cites W2090413950 @default.
• W2034224142 cites W2091811393 @default.
• W2034224142 cites W2095637897 @default.
• W2034224142 cites W2099004076 @default.
• W2034224142 cites W2100733433 @default.
• W2034224142 cites W2103621658 @default.
• W2034224142 cites W2104731571 @default.
• W2034224142 cites W2109091674 @default.
• W2034224142 cites W2112163143 @default.
• W2034224142 cites W2128521215 @default.
• W2034224142 cites W2129217278 @default.
• W2034224142 cites W2129867386 @default.
• W2034224142 cites W2130534871 @default.
• W2034224142 cites W2130674184 @default.
• W2034224142 cites W2142190440 @default.
• W2034224142 cites W2148173290 @default.
• W2034224142 cites W2150344572 @default.
• W2034224142 cites W2151662136 @default.
• W2034224142 cites W2152157708 @default.
• W2034224142 cites W2153507803 @default.
• W2034224142 cites W2154131855 @default.
• W2034224142 cites W2159030941 @default.
• W2034224142 cites W2160229277 @default.
• W2034224142 cites W2163364301 @default.
• W2034224142 cites W2167684047 @default.
• W2034224142 cites W2171629893 @default.
• W2034224142 cites W2320580054 @default.
• W2034224142 cites W4229753619 @default.
• W2034224142 cites W4298369158 @default.
• W2034224142 cites W4376595425 @default.
• W2034224142 cites W4376848430 @default.
• W2034224142 doi "https://doi.org/10.1016/j.nbd.2015.02.015" @default.

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