FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034226145> ?p ?o ?g. }

• W2034226145 endingPage "372" @default.
• W2034226145 startingPage "361" @default.
• W2034226145 abstract "The possible influence of GABAergic systems on the activity of enkephalinergic neurones within the basal ganglia was examined by measuring the release of Met-enkephalin in the caudate nuclei and pallida of halothane-anesthesized cats treated by intra-caudate applications of GABA-related drugs. Depending on the concentration used, GABA exerted local stimulatory (at 10 microM of the amino acid) or inhibitory (at 0.5 mM) action on Met-enkephalin release in the cat caudate nucleus. Only the inhibition was reproduced by the GABA agonists muscimol (1 microM) and (-)-balcofen(10 microM) and by diazepam 10 microM). Conversely, the intra-caudate application of the GABA antagonist bicuculline enhanced markedly the local release of the pentapeptide. Complementary studies using slices of the rat striatum (caudate nucleus + putamen) revealed that a low concentration of GABA (10 microM) tended to increase the K+-evoked efflux of Met-enkephalin, whereas a high concentration of the amino acid exerted a strong inhibitory effect on the peptide release. Such in vivo and in vitro findings suggest that the GABA-induced inhibition of Met-enkephalin release took place via the stimulation of specific GABA A and GABA B receptors within the caudate nucleus, whereas the GABA-induced increase of the peptide release might involve some intracellular regulatory processes in striatal neurones containing both GABA and enkephalins. In addition to altering the local release of Met-enkephalin, intra-caudate applications of GABA-related drugs affected the peptide release in the ipsilateral globus pallidus and contralateral basal ganglia. The observed changes suggest that GABA A, but not GABA B, receptors participated in some tonic inhibitory influence of striatal GABAergic neurones on the striato-pallidal enkephalinergic system. Furthermore, the present results confirmed previous studies (Bourgoin et al.) showing that GABAergic neurones can contribute to some bilateral modulation of enkephalinergic neurones within the basal ganglia." @default.
• W2034226145 created "2016-06-24" @default.
• W2034226145 creator A5001240923 @default.
• W2034226145 creator A5005549596 @default.
• W2034226145 creator A5009030222 @default.
• W2034226145 creator A5014727826 @default.
• W2034226145 creator A5038507730 @default.
• W2034226145 date "1985-12-01" @default.
• W2034226145 modified "2023-10-16" @default.
• W2034226145 title "Local and remote effects of intra-caudate administration of GABA-related drugs on met-enkephalin release in the basal ganglion" @default.
• W2034226145 cites W1152299788 @default.
• W2034226145 cites W1969982857 @default.
• W2034226145 cites W1975996671 @default.
• W2034226145 cites W1978943917 @default.
• W2034226145 cites W1981238171 @default.
• W2034226145 cites W1983328170 @default.
• W2034226145 cites W1986427250 @default.
• W2034226145 cites W1993357915 @default.
• W2034226145 cites W1994383216 @default.
• W2034226145 cites W1997075267 @default.
• W2034226145 cites W1997504468 @default.
• W2034226145 cites W2000695956 @default.
• W2034226145 cites W2006845694 @default.
• W2034226145 cites W2027712916 @default.
• W2034226145 cites W2038296494 @default.
• W2034226145 cites W2039606182 @default.
• W2034226145 cites W2048166249 @default.
• W2034226145 cites W2048684116 @default.
• W2034226145 cites W2050681583 @default.
• W2034226145 cites W2054347508 @default.
• W2034226145 cites W2056945518 @default.
• W2034226145 cites W2057216040 @default.
• W2034226145 cites W2067366123 @default.
• W2034226145 cites W2071161962 @default.
• W2034226145 cites W2071762027 @default.
• W2034226145 cites W2080196890 @default.
• W2034226145 cites W2085015621 @default.
• W2034226145 cites W2089132438 @default.
• W2034226145 cites W2092040718 @default.
• W2034226145 cites W2092427566 @default.
• W2034226145 cites W2131563938 @default.
• W2034226145 cites W2148900834 @default.
• W2034226145 cites W2162679558 @default.
• W2034226145 cites W1988336198 @default.
• W2034226145 doi "https://doi.org/10.1016/0006-8993(85)91306-x" @default.
• W2034226145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3936593" @default.
• W2034226145 hasPublicationYear "1985" @default.
• W2034226145 type Work @default.
• W2034226145 sameAs 2034226145 @default.
• W2034226145 citedByCount "14" @default.
• W2034226145 crossrefType "journal-article" @default.
• W2034226145 hasAuthorship W2034226145A5001240923 @default.
• W2034226145 hasAuthorship W2034226145A5005549596 @default.
• W2034226145 hasAuthorship W2034226145A5009030222 @default.
• W2034226145 hasAuthorship W2034226145A5014727826 @default.
• W2034226145 hasAuthorship W2034226145A5038507730 @default.
• W2034226145 hasConcept C126322002 @default.
• W2034226145 hasConcept C134018914 @default.
• W2034226145 hasConcept C168258287 @default.
• W2034226145 hasConcept C170493617 @default.
• W2034226145 hasConcept C17077164 @default.
• W2034226145 hasConcept C185592680 @default.
• W2034226145 hasConcept C2776007765 @default.
• W2034226145 hasConcept C2777803847 @default.
• W2034226145 hasConcept C2778187257 @default.
• W2034226145 hasConcept C2779177108 @default.
• W2034226145 hasConcept C2779188335 @default.
• W2034226145 hasConcept C2780062018 @default.
• W2034226145 hasConcept C2780278869 @default.
• W2034226145 hasConcept C2780763569 @default.
• W2034226145 hasConcept C2781063702 @default.
• W2034226145 hasConcept C2781423529 @default.
• W2034226145 hasConcept C513476851 @default.
• W2034226145 hasConcept C529278444 @default.
• W2034226145 hasConcept C55493867 @default.
• W2034226145 hasConcept C71924100 @default.
• W2034226145 hasConcept C79636183 @default.
• W2034226145 hasConcept C86803240 @default.
• W2034226145 hasConceptScore W2034226145C126322002 @default.
• W2034226145 hasConceptScore W2034226145C134018914 @default.
• W2034226145 hasConceptScore W2034226145C168258287 @default.
• W2034226145 hasConceptScore W2034226145C170493617 @default.
• W2034226145 hasConceptScore W2034226145C17077164 @default.
• W2034226145 hasConceptScore W2034226145C185592680 @default.
• W2034226145 hasConceptScore W2034226145C2776007765 @default.
• W2034226145 hasConceptScore W2034226145C2777803847 @default.
• W2034226145 hasConceptScore W2034226145C2778187257 @default.
• W2034226145 hasConceptScore W2034226145C2779177108 @default.
• W2034226145 hasConceptScore W2034226145C2779188335 @default.
• W2034226145 hasConceptScore W2034226145C2780062018 @default.
• W2034226145 hasConceptScore W2034226145C2780278869 @default.
• W2034226145 hasConceptScore W2034226145C2780763569 @default.
• W2034226145 hasConceptScore W2034226145C2781063702 @default.
• W2034226145 hasConceptScore W2034226145C2781423529 @default.
• W2034226145 hasConceptScore W2034226145C513476851 @default.
• W2034226145 hasConceptScore W2034226145C529278444 @default.
• W2034226145 hasConceptScore W2034226145C55493867 @default.
• W2034226145 hasConceptScore W2034226145C71924100 @default.

• next