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• W2034226710 endingPage "7722" @default.
• W2034226710 startingPage "7714" @default.
• W2034226710 abstract "The continuous production of the CXC ligand 1 (CXCL1) chemokine by melanoma cells is a major effector of tumor growth. We have previously shown that the constitutive expression of this chemokine is dependent upon transcription factors nuclear factor-kappa B (NF-κB), stimulating protein-1 (SP1), high-mobility group-I/Y (HMGI/Y), CAAT displacement protein (CDP) and poly(ADP-ribose) polymerase-1 (PARP-1). In this study, we demonstrate for the first time the mechanism of transcriptional regulation of CXCL1 through PARP-1 in melanoma cells. In its inactive state, PARP-1 binds to the CXCL1 promoter in a sequence-specific manner and prevents binding of NF-κB (p65/p50) to its element. However, activation of the PARP-1 enzymatic activity enhances CXCL1 expression, owing to the loss of PARP-1 binding to the CXCL1 promoter, accompanied by enhanced binding of p65 to the promoter. The delineation of the role of NF-κB-interacting factors in the putative CXCL1 enhanceosome will provide key information in developing strategies to block constitutive expression of this and other chemokines in cancer and to develop targeted therapy." @default.
• W2034226710 created "2016-06-24" @default.
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• W2034226710 date "2006-06-26" @default.
• W2034226710 modified "2023-10-13" @default.
• W2034226710 title "Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1" @default.
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• W2034226710 doi "https://doi.org/10.1038/sj.onc.1209751" @default.
• W2034226710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2665274" @default.
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