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• W2034227973 abstract "In vivo regulation of matrix vesicles (MV) during primary bone formation was examined using tibial marrow ablation in rats as the experimental model. The effects of bone-bonding and nonbonding implants on the number of MV/μm 2 of matrix and the alkaline phosphatase (ALPase) and phospholipase A 2 (PA 2 ) activities of MV-enriched microsomes (MVEM) isolated from the healing bone were studied. MV concentration, ALPase, and PA 2 were increased by bone-bonding implants by day 3 post-surgery; a similar effect was seen in the contralateral limb, but at a lower magnitude. Nonbonding implants had no effect at day 3 and decreased MV concentration and PA 2 activity at later time points; the same behavior was observed in the contralateral limb. These results demonstrate that MVs are influenced in a differential manner by implant materials, both locally and systemically, and can be regulated during primary mineralization." @default.
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• W2034227973 date "1992-05-01" @default.
• W2034227973 modified "2023-09-25" @default.
• W2034227973 title "In vivo regulation of matrix vesicle concentration and enzyme activity during primary bone formation" @default.
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• W2034227973 doi "https://doi.org/10.1016/0169-6009(92)90724-r" @default.
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