FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034228916> ?p ?o ?g. }

• W2034228916 endingPage "751" @default.
• W2034228916 startingPage "742" @default.
• W2034228916 abstract "In this review I report evidence that the mainstream field of oxidative damage biology has been running fast in the wrong direction for more than 50 years. Reactive oxygen species (ROS) and chronic oxidative changes in membrane lipids and proteins found in many chronic diseases are not the result of accidental damage. Instead, these changes are the result of a highly evolved, stereotyped, and protein-catalyzed “oxidative shielding” response that all eukaryotes adopt when placed in a chemically or microbially hostile environment. The machinery of oxidative shielding evolved from pathways of innate immunity designed to protect the cell from attack and limit the spread of infection. Both oxidative and reductive stress trigger oxidative shielding. In the cases in which it has been studied explicitly, functional and metabolic defects occur in the cell before the increase in ROS and oxidative changes. ROS are the response to disease, not the cause. Therefore, it is not the oxidative changes that should be targeted for therapy, but rather the metabolic conditions that create them. This fresh perspective is relevant to diseases that range from autism, type 1 diabetes, type 2 diabetes, cancer, heart disease, schizophrenia, Parkinson9s disease, and Alzheimer disease. Research efforts need to be redirected. Oxidative shielding is protective and is a misguided target for therapy. Identification of the causal chemistry and environmental factors that trigger innate immunity and metabolic memory that initiate and sustain oxidative shielding is paramount for human health." @default.
• W2034228916 created "2016-06-24" @default.
• W2034228916 creator A5074703257 @default.
• W2034228916 date "2014-12-01" @default.
• W2034228916 modified "2023-10-16" @default.
• W2034228916 title "Updated guidelines on cardiovascular evaluation before noncardiac surgery: A view from the trenches" @default.
• W2034228916 cites W1237199335 @default.
• W2034228916 cites W1532230365 @default.
• W2034228916 cites W1950893026 @default.
• W2034228916 cites W1968920736 @default.
• W2034228916 cites W1993564152 @default.
• W2034228916 cites W1995076226 @default.
• W2034228916 cites W2030475349 @default.
• W2034228916 cites W2036172774 @default.
• W2034228916 cites W2048301249 @default.
• W2034228916 cites W2048597481 @default.
• W2034228916 cites W2054436867 @default.
• W2034228916 cites W2071957228 @default.
• W2034228916 cites W2076064228 @default.
• W2034228916 cites W2078311065 @default.
• W2034228916 cites W2082691055 @default.
• W2034228916 cites W2083391328 @default.
• W2034228916 cites W2093279552 @default.
• W2034228916 cites W2103545765 @default.
• W2034228916 cites W2110843198 @default.
• W2034228916 cites W2110951173 @default.
• W2034228916 cites W2112380741 @default.
• W2034228916 cites W2116705183 @default.
• W2034228916 cites W2119340816 @default.
• W2034228916 cites W2121394112 @default.
• W2034228916 cites W2122659928 @default.
• W2034228916 cites W2131921632 @default.
• W2034228916 cites W2133051185 @default.
• W2034228916 cites W2138247049 @default.
• W2034228916 cites W2138776943 @default.
• W2034228916 cites W2147615829 @default.
• W2034228916 cites W2153291863 @default.
• W2034228916 cites W2157337113 @default.
• W2034228916 cites W2163137937 @default.
• W2034228916 cites W2165349656 @default.
• W2034228916 cites W2328595756 @default.
• W2034228916 cites W2396319370 @default.
• W2034228916 cites W2396508208 @default.
• W2034228916 cites W2616651817 @default.
• W2034228916 cites W2727340451 @default.
• W2034228916 cites W2735103047 @default.
• W2034228916 cites W2741332232 @default.
• W2034228916 doi "https://doi.org/10.3949/ccjm.81a.14148" @default.
• W2034228916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25452352" @default.
• W2034228916 hasPublicationYear "2014" @default.
• W2034228916 type Work @default.
• W2034228916 sameAs 2034228916 @default.
• W2034228916 citedByCount "4" @default.
• W2034228916 countsByYear W20342289162018 @default.
• W2034228916 countsByYear W20342289162019 @default.
• W2034228916 crossrefType "journal-article" @default.
• W2034228916 hasAuthorship W2034228916A5074703257 @default.
• W2034228916 hasBestOaLocation W20342289161 @default.
• W2034228916 hasConcept C126322002 @default.
• W2034228916 hasConcept C134018914 @default.
• W2034228916 hasConcept C136449434 @default.
• W2034228916 hasConcept C203014093 @default.
• W2034228916 hasConcept C2776151105 @default.
• W2034228916 hasConcept C2779134260 @default.
• W2034228916 hasConcept C48349386 @default.
• W2034228916 hasConcept C55493867 @default.
• W2034228916 hasConcept C555293320 @default.
• W2034228916 hasConcept C57600042 @default.
• W2034228916 hasConcept C60644358 @default.
• W2034228916 hasConcept C71924100 @default.
• W2034228916 hasConcept C86803240 @default.
• W2034228916 hasConcept C8891405 @default.
• W2034228916 hasConcept C95444343 @default.
• W2034228916 hasConceptScore W2034228916C126322002 @default.
• W2034228916 hasConceptScore W2034228916C134018914 @default.
• W2034228916 hasConceptScore W2034228916C136449434 @default.
• W2034228916 hasConceptScore W2034228916C203014093 @default.
• W2034228916 hasConceptScore W2034228916C2776151105 @default.
• W2034228916 hasConceptScore W2034228916C2779134260 @default.
• W2034228916 hasConceptScore W2034228916C48349386 @default.
• W2034228916 hasConceptScore W2034228916C55493867 @default.
• W2034228916 hasConceptScore W2034228916C555293320 @default.
• W2034228916 hasConceptScore W2034228916C57600042 @default.
• W2034228916 hasConceptScore W2034228916C60644358 @default.
• W2034228916 hasConceptScore W2034228916C71924100 @default.
• W2034228916 hasConceptScore W2034228916C86803240 @default.
• W2034228916 hasConceptScore W2034228916C8891405 @default.
• W2034228916 hasConceptScore W2034228916C95444343 @default.
• W2034228916 hasIssue "12" @default.
• W2034228916 hasLocation W20342289161 @default.
• W2034228916 hasLocation W20342289162 @default.
• W2034228916 hasOpenAccess W2034228916 @default.
• W2034228916 hasPrimaryLocation W20342289161 @default.
• W2034228916 hasRelatedWork W1807700271 @default.
• W2034228916 hasRelatedWork W1971924540 @default.
• W2034228916 hasRelatedWork W2046122050 @default.
• W2034228916 hasRelatedWork W2083268376 @default.
• W2034228916 hasRelatedWork W2120278390 @default.

• next