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- W2034229025 abstract "<i>Background:</i> DNA synthesis is significantly more stimulated in response to insulin-like growth factor I (IGF-I) in growth-arrested cultures of psoriatic than of nonpsoriatic keratinocytes. Epidermal growth factor (EGF), by itself only a weak stimulator, was recently found to cause a strong synergetic effect when added together with IGF-I to newborn human keratinocytes. <i>Objective:</i> (1) To measure this effect in cultured adult psoriatic and nonpsoriatic keratinocytes, and (2) to examine whether the difference in DNA synthesis after IGF-I addition could be due to differences in the binding of this growth factor. <i>Methods:</i><sup>3</sup>H-deoxythymidine incorporation and <sup>125</sup>I-IGF-I binding studies. <i>Results:</i> Psoriatic keratinocytes demonstrate a considerably stronger response to the combination of EGF and IGF-I than nonpsoriatic keratinocytes. This is apparently not caused by differences in binding of IGF-I. <i>Conclusion:</i> Differences in the proliferative rate of normal and psoriatic keratinocytes may be in part due to differences in signal transduction distal from the IGF-I receptor or in the cooperation of the EGF and the IGF-I receptor." @default.
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- W2034229025 title "Increased Synergistic Effect of EGF and IGF-I on DNA Synthesis of Cultured Psoriatic Keratinocytes" @default.
- W2034229025 doi "https://doi.org/10.1159/000245945" @default.
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