Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034229074> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2034229074 endingPage "116" @default.
- W2034229074 startingPage "111" @default.
- W2034229074 abstract "The pncA gene mutations associated with pyrazinamide (PZA) resistance in Mycobacterium tuberculosis complex were determined in 26 PZA-resistant isolates in Japan. Of the 26 PZA-resistant isolates included, 21 were negative for pyrazinamidase (PZase). Of these, 20 isolates had various pncA mutations, resulting in alteration of primary amino acid sequence. However, 1 PZase-negative isolate did not have any mutation on pncA gene. The remaining 5 PZA-resistant isolates were positive for PZase and had identical pncA alleles with PZA-susceptible isolates. IS6110 RFLP analysis demonstrated various distinct IS6110 types and 5 pairs of isolates were very close to each other (>90% identical pattern). This study demonstrates that most of the PZA resistance is a result of various mutations on pncA resulting in loss of PZase activity. Further investigation, particularly on PZase-positive but PZA-resistant isolates and a PZase-negative isolate with no mutation on pncA, should be urgently done." @default.
- W2034229074 created "2016-06-24" @default.
- W2034229074 creator A5022345064 @default.
- W2034229074 creator A5038434547 @default.
- W2034229074 creator A5049924190 @default.
- W2034229074 creator A5062915930 @default.
- W2034229074 creator A5068202119 @default.
- W2034229074 date "2004-02-01" @default.
- W2034229074 modified "2023-10-10" @default.
- W2034229074 title "Genetic and phenotypic characterization of pyrazinamide-resistant mycobacterium tuberculosis complex isolates in Japan" @default.
- W2034229074 cites W1890317675 @default.
- W2034229074 cites W1963975384 @default.
- W2034229074 cites W1986538901 @default.
- W2034229074 cites W2065130119 @default.
- W2034229074 cites W2076272552 @default.
- W2034229074 cites W2098335911 @default.
- W2034229074 cites W2100887397 @default.
- W2034229074 cites W2115727302 @default.
- W2034229074 cites W2143867022 @default.
- W2034229074 cites W2149808870 @default.
- W2034229074 cites W2154718868 @default.
- W2034229074 cites W2159500985 @default.
- W2034229074 doi "https://doi.org/10.1016/j.diagmicrobio.2003.09.013" @default.
- W2034229074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14972380" @default.
- W2034229074 hasPublicationYear "2004" @default.
- W2034229074 type Work @default.
- W2034229074 sameAs 2034229074 @default.
- W2034229074 citedByCount "21" @default.
- W2034229074 countsByYear W20342290742012 @default.
- W2034229074 countsByYear W20342290742013 @default.
- W2034229074 countsByYear W20342290742015 @default.
- W2034229074 countsByYear W20342290742016 @default.
- W2034229074 countsByYear W20342290742021 @default.
- W2034229074 countsByYear W20342290742022 @default.
- W2034229074 crossrefType "journal-article" @default.
- W2034229074 hasAuthorship W2034229074A5022345064 @default.
- W2034229074 hasAuthorship W2034229074A5038434547 @default.
- W2034229074 hasAuthorship W2034229074A5049924190 @default.
- W2034229074 hasAuthorship W2034229074A5062915930 @default.
- W2034229074 hasAuthorship W2034229074A5068202119 @default.
- W2034229074 hasConcept C104317684 @default.
- W2034229074 hasConcept C142724271 @default.
- W2034229074 hasConcept C2777975735 @default.
- W2034229074 hasConcept C2778607973 @default.
- W2034229074 hasConcept C2780459521 @default.
- W2034229074 hasConcept C2781069245 @default.
- W2034229074 hasConcept C501593827 @default.
- W2034229074 hasConcept C501734568 @default.
- W2034229074 hasConcept C54355233 @default.
- W2034229074 hasConcept C71924100 @default.
- W2034229074 hasConcept C86803240 @default.
- W2034229074 hasConcept C89423630 @default.
- W2034229074 hasConceptScore W2034229074C104317684 @default.
- W2034229074 hasConceptScore W2034229074C142724271 @default.
- W2034229074 hasConceptScore W2034229074C2777975735 @default.
- W2034229074 hasConceptScore W2034229074C2778607973 @default.
- W2034229074 hasConceptScore W2034229074C2780459521 @default.
- W2034229074 hasConceptScore W2034229074C2781069245 @default.
- W2034229074 hasConceptScore W2034229074C501593827 @default.
- W2034229074 hasConceptScore W2034229074C501734568 @default.
- W2034229074 hasConceptScore W2034229074C54355233 @default.
- W2034229074 hasConceptScore W2034229074C71924100 @default.
- W2034229074 hasConceptScore W2034229074C86803240 @default.
- W2034229074 hasConceptScore W2034229074C89423630 @default.
- W2034229074 hasFunder F4320320912 @default.
- W2034229074 hasIssue "2" @default.
- W2034229074 hasLocation W20342290741 @default.
- W2034229074 hasLocation W20342290742 @default.
- W2034229074 hasOpenAccess W2034229074 @default.
- W2034229074 hasPrimaryLocation W20342290741 @default.
- W2034229074 hasRelatedWork W2042252940 @default.
- W2034229074 hasRelatedWork W2110949356 @default.
- W2034229074 hasRelatedWork W2183266068 @default.
- W2034229074 hasRelatedWork W2493613850 @default.
- W2034229074 hasRelatedWork W2791697302 @default.
- W2034229074 hasRelatedWork W2896632005 @default.
- W2034229074 hasRelatedWork W2972094210 @default.
- W2034229074 hasRelatedWork W3210687582 @default.
- W2034229074 hasRelatedWork W4210506554 @default.
- W2034229074 hasRelatedWork W4308058527 @default.
- W2034229074 hasVolume "48" @default.
- W2034229074 isParatext "false" @default.
- W2034229074 isRetracted "false" @default.
- W2034229074 magId "2034229074" @default.
- W2034229074 workType "article" @default.