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- W2034229129 abstract "Publisher Summary This chapter describes the halogen substitution of amphetamine biochemical and pharmacological consequences. p -Chlorinated derivatives of amphetamine exert pharmacological effects which are similar to those of the parent compounds. In contrast to amphetamine, p -chloroamphetamine (PCA) PCA does not alter the concentration of either norepinephrine, or dopamine in brain but markedly changes the metabolism of cerebral serotonin. The initial central excitatory action of PCA is like that of amphetamine, related to its effect on the metabolism of cerebral catecholamines. Like amphetamine, PCA causes a large increase in the concentration of normetanephrine, and a reduction in the levels of the deaminated metabolites of 3 H-norepinephrine. Accordingly, similar mechanisms might be responsible for the effects such as release of catecholamines, blockade of their reuptake, and possibly either direct inhibition of MAO, or indirect inhibition of the enzyme resulting from the blockade of neuronal uptake of catecholamines. The effects elicited by PCA on the metabolism of 3 H-norepinephrine are, however, more pronounced and longer lasting in accordance with its longer biological half-life." @default.
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- W2034229129 date "1974-04-01" @default.
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- W2034229129 title "Halogen substitution of amphetamine biochemical and pharmacological consequences" @default.
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