FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034232173> ?p ?o ?g. }

• W2034232173 endingPage "IN8" @default.
• W2034232173 startingPage "174" @default.
• W2034232173 abstract "We previously identified cystatin C (CystC) as a novel antagonist of transforming growth factor β (TGF-β) signaling in normal and malignant cells. However, whether the anti-TGF-β activities of CystC can be translated to preclinical animal models of breast cancer growth and metastasis remains unproven. Assessing the preclinical efficacy of CystC was accomplished using metastatic 4T1 breast cancer cells, whose oncogenic responses to TGF-β were inhibited both in vitro and in vivo. Indeed, we observed CystC to prevent TGF-β from stimulating the growth and pulmonary metastasis of 4T1 tumors in mice in part by reducing the extent of Smad2, p38 mitogen-activated protein kinase, and extracellular signal-regulated kinase 1/2 phosphorylation present in 4T1 tumors. We also found CystC to significantly antagonize angiogenesis in developing 4T1 tumors, suggesting a novel role for CystC in uncoupling TGF-β signaling in endothelial cells (ECs). Accordingly, CystC dramatically reduced murine and human EC responsiveness to TGF-β, including their ability to regulate the expression of 1) TGF-β signaling components, 2) inhibitor of differentiation (ID) family members, and 3) matrix metalloproteinases and their inhibitors (TIMPs) and to undergo cell invasion and angiogenic sprouting stimulated by TGF-β. Importantly, CystC prevented TGF-β from stimulating vessel development in Matrigel plugs implanted into genetically normal mice. Collectively, our findings provide the first preclinical evidence that CystC is efficacious in preventing breast cancer progression and angiogenesis stimulated by the oncogenic TGF-β signaling system and suggest that CystC-based chemotherapeutics possesses translational efficacy to one day treat and improve the clinical course of late-stage breast cancers." @default.
• W2034232173 created "2016-06-24" @default.
• W2034232173 creator A5063812000 @default.
• W2034232173 creator A5090145675 @default.
• W2034232173 date "2009-09-01" @default.
• W2034232173 modified "2023-09-25" @default.
• W2034232173 title "Preclinical Efficacy of Cystatin C to Target the Oncogenic Activity of Transforming Growth Factor β in Breast Cancer" @default.
• W2034232173 cites W1573363574 @default.
• W2034232173 cites W1958564793 @default.
• W2034232173 cites W1978999523 @default.
• W2034232173 cites W1983426701 @default.
• W2034232173 cites W1984162437 @default.
• W2034232173 cites W1986563355 @default.
• W2034232173 cites W1988613013 @default.
• W2034232173 cites W1993992129 @default.
• W2034232173 cites W1995827857 @default.
• W2034232173 cites W1996427377 @default.
• W2034232173 cites W2002606648 @default.
• W2034232173 cites W2011491605 @default.
• W2034232173 cites W2012362519 @default.
• W2034232173 cites W2015959969 @default.
• W2034232173 cites W2016394200 @default.
• W2034232173 cites W2016787903 @default.
• W2034232173 cites W2021605609 @default.
• W2034232173 cites W2024888501 @default.
• W2034232173 cites W2026325139 @default.
• W2034232173 cites W2028476252 @default.
• W2034232173 cites W2037038224 @default.
• W2034232173 cites W2039787319 @default.
• W2034232173 cites W2039815807 @default.
• W2034232173 cites W2042773343 @default.
• W2034232173 cites W2049690785 @default.
• W2034232173 cites W2056933970 @default.
• W2034232173 cites W2057216898 @default.
• W2034232173 cites W2057254477 @default.
• W2034232173 cites W2057539625 @default.
• W2034232173 cites W2063868306 @default.
• W2034232173 cites W2064450320 @default.
• W2034232173 cites W2071970475 @default.
• W2034232173 cites W2075550764 @default.
• W2034232173 cites W2077277355 @default.
• W2034232173 cites W2080036995 @default.
• W2034232173 cites W2086801198 @default.
• W2034232173 cites W2090985686 @default.
• W2034232173 cites W2091215847 @default.
• W2034232173 cites W2093891196 @default.
• W2034232173 cites W2097619603 @default.
• W2034232173 cites W2098282622 @default.
• W2034232173 cites W2110924026 @default.
• W2034232173 cites W2111769468 @default.
• W2034232173 cites W2121946269 @default.
• W2034232173 cites W2124836729 @default.
• W2034232173 cites W2130525687 @default.
• W2034232173 cites W2130870648 @default.
• W2034232173 cites W2131189959 @default.
• W2034232173 cites W2153203105 @default.
• W2034232173 cites W2156051913 @default.
• W2034232173 cites W2163504684 @default.
• W2034232173 cites W2166859762 @default.
• W2034232173 cites W4292964442 @default.
• W2034232173 doi "https://doi.org/10.1593/tlo.09145" @default.
• W2034232173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2730134" @default.
• W2034232173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19701502" @default.
• W2034232173 hasPublicationYear "2009" @default.
• W2034232173 type Work @default.
• W2034232173 sameAs 2034232173 @default.
• W2034232173 citedByCount "24" @default.
• W2034232173 countsByYear W20342321732014 @default.
• W2034232173 countsByYear W20342321732015 @default.
• W2034232173 countsByYear W20342321732016 @default.
• W2034232173 countsByYear W20342321732017 @default.
• W2034232173 countsByYear W20342321732018 @default.
• W2034232173 countsByYear W20342321732019 @default.
• W2034232173 countsByYear W20342321732020 @default.
• W2034232173 countsByYear W20342321732021 @default.
• W2034232173 countsByYear W20342321732023 @default.
• W2034232173 crossrefType "journal-article" @default.
• W2034232173 hasAuthorship W2034232173A5063812000 @default.
• W2034232173 hasAuthorship W2034232173A5090145675 @default.
• W2034232173 hasBestOaLocation W20342321731 @default.
• W2034232173 hasConcept C118131993 @default.
• W2034232173 hasConcept C121608353 @default.
• W2034232173 hasConcept C126322002 @default.
• W2034232173 hasConcept C2779013556 @default.
• W2034232173 hasConcept C2780394083 @default.
• W2034232173 hasConcept C502942594 @default.
• W2034232173 hasConcept C530470458 @default.
• W2034232173 hasConcept C57074206 @default.
• W2034232173 hasConcept C62478195 @default.
• W2034232173 hasConcept C71924100 @default.
• W2034232173 hasConcept C86803240 @default.
• W2034232173 hasConcept C95444343 @default.
• W2034232173 hasConceptScore W2034232173C118131993 @default.
• W2034232173 hasConceptScore W2034232173C121608353 @default.
• W2034232173 hasConceptScore W2034232173C126322002 @default.
• W2034232173 hasConceptScore W2034232173C2779013556 @default.
• W2034232173 hasConceptScore W2034232173C2780394083 @default.
• W2034232173 hasConceptScore W2034232173C502942594 @default.

• next