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• W2034232887 abstract "Dentin formation is preferred in the healing response of the pulp to pulp‐capping agents during vital pulp therapy. Enhancement of the dentinogenic differentiation of dental pulp cells is thought to accelerate pulp repair. The aim of this study was to evaluate the dentinogenic activity of small molecules (three flavonoids and phenamil) that have been shown previously to induce osteoblast differentiation. Among the flavonoids (quercetin, genistein and baicalin), quercetin induced the highest alkaline phosphatase ( ALP ) activity of human dental pulp ( HDP ) cells. Phenamil, an amiloride derivative, elicited higher ALP activity than quercetin. However, increased expression of dentin sialophosphoprotein ( DSPP ) m RNA and mineral deposition were seen in cultures treated with quercetin compared with phenamil. This would seem to suggest that quercetin is the most dentinogenic agent among the tested chemicals. The increase in ALP activity in the quercetin‐treated cells was not affected by ICI 182,780, an estrogen receptor inhibitor, and was partially blocked by PD 98059, an extracellular signal‐regulated kinase 1/2 ( ERK 1/2) inhibitor. This suggests that ERK 1/2 is activated in the quercetin‐induced differentiation of HDP cells without the mediation of estrogen receptors, which are known to be involved in osteoblast differentiation induced by quercetin." @default.
• W2034232887 created "2016-06-24" @default.
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• W2034232887 date "2013-09-17" @default.
• W2034232887 modified "2023-10-16" @default.
• W2034232887 title "Stimulating effects of quercetin and phenamil on differentiation of human dental pulp cells" @default.
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• W2034232887 doi "https://doi.org/10.1111/eos.12086" @default.
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