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- W2034233007 abstract "The objective of this study was to investigate the suitability of carbohydrate plasma volume expanders as a novel polymer platform for tumor targeting. Many synthetic polymers have already been synthesized for targeted tumor therapy, but potential advantages of these carbohydrates include inexpensive synthesis, constant availability, a good safety profile, biodegradability and the long clinical use as plasma expanders. Three polymers have been tested for cytotoxicity and cytokine activation in cell cultures and conjugated with a near-infrared fluorescent dye: hydroxyethyl starches (HES 200 kDa and HES 450 kDa) and dextran (DEX 500 kDa). Particle size and molecular weight distribution were determined by asymmetric flow field-flow fractionation (AF4). The biodistribution was investigated non-invasively in nude mice using multispectral optical imaging. The most promising polymer conjugate was characterized in human colon carcinoma xenograft bearing nude mice. A tumor specific accumulation of HES 450 was observed, which proves it's potential as carrier for passive tumor targeting." @default.
- W2034233007 created "2016-06-24" @default.
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- W2034233007 date "2013-06-01" @default.
- W2034233007 modified "2023-09-29" @default.
- W2034233007 title "Carbohydrate plasma expanders for passive tumor targeting: In vitro and in vivo studies" @default.
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- W2034233007 doi "https://doi.org/10.1016/j.carbpol.2013.03.033" @default.
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