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- W2034235609 abstract "Roscovitine is a potent CDK inhibitor often used as a biological tool in cell-cycle studies, but its working mechanism and real targets in vascular smooth muscle cells (VSMCs) remain unclear. In this study, we observed that ERK1/2 phosphorylation induced by Ang II was abrogated by pretreating VSMCs with roscovitine for 15h. Pretreating VSMCs with roscovitine also inhibited Ang II-induced c-Jun expression and phosphorylation. We further demonstrated that roscovitine could suppress the DNA binding activity of c-Jun and activation of angiotensinogen promoter by Ang II. These results suggest that roscovitine represses Ang II-induced angiotensinogen expression by inhibiting activation of ERK1/2 and c-Jun." @default.
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- W2034235609 date "2007-12-18" @default.
- W2034235609 modified "2023-10-17" @default.
- W2034235609 title "Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells" @default.
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- W2034235609 doi "https://doi.org/10.1016/j.febslet.2007.12.011" @default.
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