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• W2034236473 abstract "Cancer procoagulant (CP), EC 3.4.22.26, is a cysteine proteinase produced by undifferentiated (fetal) or dedifferentiated (malignant) tissue [ 1 GORDON S.G Cancer cell procoagulants and their role in malignant disease. Seminars in Thromb. Hemost. 1992; 63: 424-433 Crossref Scopus (60) Google Scholar ]. Recent studies have highlighted the potential of CP as a sensitive and specific early stage tumor marker [ 2 GORDON S.G CROSS B.A An enzyme-linked immunosorbent assay for cancer procoagulant and its potential as new tumor marker. Cancer Res. 1990; 50: 6229-6234 PubMed Google Scholar , 3 KOZWICH D.L KRAMER L.C MIELICKI W.P FOTOPOULOS S.S GORDON S.G Application of cancer procoagulant as an early detection tumor marker. Cancer. 1994; 74: 1367-1376 Crossref PubMed Scopus (48) Google Scholar ]. The only known physiological substrate for CP is coagulation factor X [ 6 GORDON S.G MOURAD A.M The site of activation of factor X by cancer procoagulant. Blood Coag. Fibrinol. 1991; 2: 735-739 Crossref PubMed Scopus (36) Google Scholar , 7 DONATI M.B RONCAGLIONI M.C FALANGA A CASALI B SEMERARO N Vitamin K-dependent procoagulant in cancer cells: a potential target for the antimetastatic effect of warfarin?. Haemostasis. 1986; 16: 288-294 PubMed Google Scholar ]. However, CP activates factor X by cleaving its heavy chain at a different site than other known factor X activators [ 8 MIELICKI W.P KOZWICH D.L KRAMER L.C GORDON S.G Effect of divalent ions on the activity of cancer procoagulant. Arch. Biochem. Biophys. 1994; 314: 165-170 Crossref PubMed Scopus (11) Google Scholar ]. There is indirect evidence that the factor X-activating activity of CP is vitamin K-dependent [ 4 GORDON S.G CROSS B.A A factor X-activating cysteine protease from malignant tissue. J. Clin. Invest. 1981; 67: 1665-1671 Crossref PubMed Scopus (202) Google Scholar ]. Certain divalent cations affect CP activity, acting in a region different from the active site of the enzyme [ 5 FALANGA A GORDON S.G Isolation and characterization of cancer procoagulant: A cysteine proteinase from malignant tissue. Biochemistry. 1985; 24: 5558-5567 Crossref PubMed Scopus (214) Google Scholar ]. The knowledge about the CP active site configuration, the preferred substrate structure and kinetic characteristics is still incomplete. There is evidence that CP has a substrate specificity similar to thrombin [ 9 MOORE W.R The purification and properties of cancer procoagulant from murine tumors. Biochem. Biophys. Res. Commun. 1992; 184: 819-824 Crossref PubMed Scopus (8) Google Scholar ]. However, kinetic constants were not calculated, making quantitative comparison of substrate preferences impossible." @default.
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• W2034236473 title "CANCER PROCOAGULANT ACTIVITY STUDIES USING SYNTHETIC PEPTIDYL SUBSTRATES" @default.
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