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- W2034237036 abstract "Two new indole alkaloids, cadambinic acid (1) and isonauclefidine (2), were isolated from the bark of Anthocephalus chinensis. The structures were identified by spectroscopic methods, and the compounds were tested for their biological activities. Both compounds showed weak cytotoxicities against A549, BGC-823, and HeLa cells in biological assays. Introduction. - The genus Anthocephalus is a member of the tribe Naucleaceae in the family Rubiaceae, which is abundant and distributed widely in southern Asia and southern China. Their barks have been used to treat uterine complaints, blood disease, leprosy, and dysentery inAyurvedoof ancient Indian medicine (1). In Indonesia, the plant is used to treat malaria (2). These medicinal functions have attracted attention in medical circles of many countries. Many compounds have been isolated from these plants, such as alkaloids (3 - 9) and triterpenoid glycosides (10 - 14). During our search for bioactive components from A. chinensis, we isolated two new indole alkaloids, 1 and 2, from the bark. Here we report the isolation and structure elucidation of these new compounds (Fig. 1), including the results of their biological assays." @default.
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- W2034237036 date "2011-08-01" @default.
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- W2034237036 title "Two New Indole Alkaloids from the Bark of Anthocephalus chinensis" @default.
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- W2034237036 doi "https://doi.org/10.1002/hlca.201100038" @default.
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