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- W2034237495 abstract "Background: The Tibetan herbal preparation Padma 28 has been shown to act as an anti-atherosclerotic agent in advanced peripheral arterial occlusive disease. We tested the effect of aqueous Padma 28 extracts on both the Creactive protein (CRP) induced expression of the pro-inflammatory cell adhesion molecule E-selectin and the anti-atherosclerotic protective enzyme heme oxygenase- 1 (HO-1) in human aortic endothelial cells. Methods and Results: According to FACS analysis, quantitative RT-PCR and Western blot, CRP-induced E-selectin expression was completely prevented by aqueous Padma 28 extracts. Additionally, Padma 28 mediated an up to 60-fold upregulation of HO-1 mRNA as measured by quantitative RT-PCR. This upregulation could also be demonstrated on the protein level. Conclusion: Aqueous extracts of the Tibetan herbal preparation Padma 28 inhibit CRP-induced expression of the inflammatory cell adhesion molecule E-selectin and lead to upregulation of the vascular protective enzyme HO-1 in human aortic endothelial cells. These properties may be responsible for its antiatherosclerotic effects in peripheral arterial occlusive disease." @default.
- W2034237495 created "2016-06-24" @default.
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- W2034237495 date "2006-01-01" @default.
- W2034237495 modified "2023-09-27" @default.
- W2034237495 title "Anti-Inflammatory Mechanisms of the Tibetan Herbal Preparation Padma 28 in the Vessel Wall" @default.
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- W2034237495 doi "https://doi.org/10.1159/000090435" @default.
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