FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034239110> ?p ?o ?g. }

• W2034239110 endingPage "7577" @default.
• W2034239110 startingPage "7568" @default.
• W2034239110 abstract "The gene that is mutated in ataxia-telangiectasia (A-T), ATM, is catalytically activated in response to DNA damage. Yet a full accounting for the CNS deficits in human A-T or its mouse models remains elusive. We have analyzed the CNS phenotypes of two mouse Atm alleles— Atm tm1Bal ( Bal ) and Atm tm1Awb ( Awb ). Neither mutant has detectable mRNA or protein in peripheral tissues. In brain, although Bal/Bal mice have no ATM protein, they have nearly normal amounts of Atm mRNA. Bal/Bal neurons exhibit extensive cell cycle reentry and degeneration in both cortex and cerebellum. Unexpectedly, in Awb/Awb mice a novel mRNA is found in which the engineered mutation is excised. This mRNA is apparently translated and produces a catalytically active ATM protein that responds to DNA damage by phosphorylating p53 and Chk2. Prompted by these results, we examined eight cases of human A-T and found evidence for residual ATM protein in seven of them. These findings offer important new insights into the human disease and the role of brain ATM activity in the severity of the neurological symptoms of A-T." @default.
• W2034239110 created "2016-06-24" @default.
• W2034239110 creator A5019963761 @default.
• W2034239110 creator A5032456908 @default.
• W2034239110 creator A5040650353 @default.
• W2034239110 creator A5060390908 @default.
• W2034239110 creator A5084208504 @default.
• W2034239110 date "2011-05-18" @default.
• W2034239110 modified "2023-10-06" @default.
• W2034239110 title "Stable Brain<i>ATM</i>Message and Residual Kinase-Active ATM Protein in Ataxia-Telangiectasia" @default.
• W2034239110 cites W1966034642 @default.
• W2034239110 cites W1997347772 @default.
• W2034239110 cites W2004486431 @default.
• W2034239110 cites W2019420937 @default.
• W2034239110 cites W2028749179 @default.
• W2034239110 cites W2033200608 @default.
• W2034239110 cites W2046589688 @default.
• W2034239110 cites W2071674290 @default.
• W2034239110 cites W2079414750 @default.
• W2034239110 cites W2087367816 @default.
• W2034239110 cites W2088013332 @default.
• W2034239110 cites W2106087857 @default.
• W2034239110 cites W2115322319 @default.
• W2034239110 cites W2134365342 @default.
• W2034239110 cites W2148534836 @default.
• W2034239110 cites W2155374906 @default.
• W2034239110 cites W2159168998 @default.
• W2034239110 cites W2170085947 @default.
• W2034239110 cites W2172192445 @default.
• W2034239110 cites W2320372555 @default.
• W2034239110 cites W4235424059 @default.
• W2034239110 cites W4294184109 @default.
• W2034239110 doi "https://doi.org/10.1523/jneurosci.0778-11.2011" @default.
• W2034239110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3109425" @default.
• W2034239110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21593342" @default.
• W2034239110 hasPublicationYear "2011" @default.
• W2034239110 type Work @default.
• W2034239110 sameAs 2034239110 @default.
• W2034239110 citedByCount "24" @default.
• W2034239110 countsByYear W20342391102012 @default.
• W2034239110 countsByYear W20342391102013 @default.
• W2034239110 countsByYear W20342391102014 @default.
• W2034239110 countsByYear W20342391102015 @default.
• W2034239110 countsByYear W20342391102016 @default.
• W2034239110 countsByYear W20342391102018 @default.
• W2034239110 countsByYear W20342391102019 @default.
• W2034239110 countsByYear W20342391102020 @default.
• W2034239110 countsByYear W20342391102021 @default.
• W2034239110 countsByYear W20342391102023 @default.
• W2034239110 crossrefType "journal-article" @default.
• W2034239110 hasAuthorship W2034239110A5019963761 @default.
• W2034239110 hasAuthorship W2034239110A5032456908 @default.
• W2034239110 hasAuthorship W2034239110A5040650353 @default.
• W2034239110 hasAuthorship W2034239110A5060390908 @default.
• W2034239110 hasAuthorship W2034239110A5084208504 @default.
• W2034239110 hasBestOaLocation W20342391101 @default.
• W2034239110 hasConcept C104317684 @default.
• W2034239110 hasConcept C105580179 @default.
• W2034239110 hasConcept C127716648 @default.
• W2034239110 hasConcept C143065580 @default.
• W2034239110 hasConcept C143425029 @default.
• W2034239110 hasConcept C153911025 @default.
• W2034239110 hasConcept C169760540 @default.
• W2034239110 hasConcept C2779486608 @default.
• W2034239110 hasConcept C2779652256 @default.
• W2034239110 hasConcept C501734568 @default.
• W2034239110 hasConcept C502942594 @default.
• W2034239110 hasConcept C54355233 @default.
• W2034239110 hasConcept C552990157 @default.
• W2034239110 hasConcept C86803240 @default.
• W2034239110 hasConcept C95444343 @default.
• W2034239110 hasConceptScore W2034239110C104317684 @default.
• W2034239110 hasConceptScore W2034239110C105580179 @default.
• W2034239110 hasConceptScore W2034239110C127716648 @default.
• W2034239110 hasConceptScore W2034239110C143065580 @default.
• W2034239110 hasConceptScore W2034239110C143425029 @default.
• W2034239110 hasConceptScore W2034239110C153911025 @default.
• W2034239110 hasConceptScore W2034239110C169760540 @default.
• W2034239110 hasConceptScore W2034239110C2779486608 @default.
• W2034239110 hasConceptScore W2034239110C2779652256 @default.
• W2034239110 hasConceptScore W2034239110C501734568 @default.
• W2034239110 hasConceptScore W2034239110C502942594 @default.
• W2034239110 hasConceptScore W2034239110C54355233 @default.
• W2034239110 hasConceptScore W2034239110C552990157 @default.
• W2034239110 hasConceptScore W2034239110C86803240 @default.
• W2034239110 hasConceptScore W2034239110C95444343 @default.
• W2034239110 hasIssue "20" @default.
• W2034239110 hasLocation W20342391101 @default.
• W2034239110 hasLocation W20342391102 @default.
• W2034239110 hasLocation W20342391103 @default.
• W2034239110 hasLocation W20342391104 @default.
• W2034239110 hasOpenAccess W2034239110 @default.
• W2034239110 hasPrimaryLocation W20342391101 @default.
• W2034239110 hasRelatedWork W1968643238 @default.
• W2034239110 hasRelatedWork W2030205636 @default.
• W2034239110 hasRelatedWork W2034103052 @default.
• W2034239110 hasRelatedWork W2054701101 @default.
• W2034239110 hasRelatedWork W2061773357 @default.

• next