FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034239309> ?p ?o ?g. }

• W2034239309 endingPage "829" @default.
• W2034239309 startingPage "822" @default.
• W2034239309 abstract "There is an association between infection, inflammation and acute cardiovascular events. In an attempt to explore the mechanism of this association we have developed a model to examine the effects on endothelial function of a brief exposure to endotoxin. Methods and results: Endotoxin was instilled into isolated superficial hand veins of healthy volunteers. The vein was isolated by means of two wedges and endotoxin instilled into the isolated segment. After 1 h the contents of the vein were aspirated and the wedges removed. Dose-response curves to bradykinin (a stimulator of nitric oxide synthesis), arachidonic acid (the precursor of prostanoid production) and GTN (a nitric oxide donor) were constructed before and 1 h after endotoxin. Endotoxin caused a glucocorticoid-inhibitable attenuation in the dose-response curves to bradykinin and arachidonic acid (P < 0.05). This effect persisted for 48 h and took 7 days to recover. Exposure of saphenous vein to endotoxin in vitro also caused selective impairment of endothelium-dependent relaxation (P < 0.05) yet microscopy of the vessels exposed to endotoxin showed no endothelial denudation or structural damage. Conclusion: The results demonstrate that a brief local exposure to endotoxin causes endothelial dysfunction that persists for 48 h and takes up to 7 days to recover. The endothelial dysfunction is not due to expression of the inducible isoform of nitric oxide synthase and persists for far longer than the effects of endotoxin on vascular smooth muscle function. We have coined the term endothelial “stunning” to describe the transient endothelial dysfunction and suggest it might provide a mechanism underpinning the association between infection or inflammation and increased cardiovascular risk. Endothelial stunning appears to provide a novel, transient, variable and modifiable potential cardiovascular risk factor." @default.
• W2034239309 created "2016-06-24" @default.
• W2034239309 creator A5018179985 @default.
• W2034239309 creator A5031460253 @default.
• W2034239309 creator A5044594207 @default.
• W2034239309 creator A5073267685 @default.
• W2034239309 date "1996-11-01" @default.
• W2034239309 modified "2023-10-01" @default.
• W2034239309 title "Endothelial stunning following a brief exposure to endotoxin: a mechanism to link infection and infarction?" @default.
• W2034239309 cites W118128547 @default.
• W2034239309 cites W1609977045 @default.
• W2034239309 cites W2047088353 @default.
• W2034239309 cites W2050129788 @default.
• W2034239309 cites W2065880835 @default.
• W2034239309 cites W2067338751 @default.
• W2034239309 cites W2089593001 @default.
• W2034239309 cites W2092620816 @default.
• W2034239309 cites W2093585097 @default.
• W2034239309 cites W2125642970 @default.
• W2034239309 cites W2133098776 @default.
• W2034239309 cites W2145570729 @default.
• W2034239309 cites W2154727737 @default.
• W2034239309 cites W2169182236 @default.
• W2034239309 cites W2221887158 @default.
• W2034239309 cites W2261738500 @default.
• W2034239309 cites W2315575691 @default.
• W2034239309 cites W2327269495 @default.
• W2034239309 cites W2397490831 @default.
• W2034239309 cites W2409379747 @default.
• W2034239309 cites W2409674759 @default.
• W2034239309 doi "https://doi.org/10.1016/s0008-6363(96)00123-x" @default.
• W2034239309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8944812" @default.
• W2034239309 hasPublicationYear "1996" @default.
• W2034239309 type Work @default.
• W2034239309 sameAs 2034239309 @default.
• W2034239309 citedByCount "58" @default.
• W2034239309 countsByYear W20342393092012 @default.
• W2034239309 countsByYear W20342393092013 @default.
• W2034239309 countsByYear W20342393092014 @default.
• W2034239309 countsByYear W20342393092015 @default.
• W2034239309 countsByYear W20342393092017 @default.
• W2034239309 countsByYear W20342393092019 @default.
• W2034239309 countsByYear W20342393092020 @default.
• W2034239309 countsByYear W20342393092022 @default.
• W2034239309 crossrefType "journal-article" @default.
• W2034239309 hasAuthorship W2034239309A5018179985 @default.
• W2034239309 hasAuthorship W2034239309A5031460253 @default.
• W2034239309 hasAuthorship W2034239309A5044594207 @default.
• W2034239309 hasAuthorship W2034239309A5073267685 @default.
• W2034239309 hasBestOaLocation W20342393091 @default.
• W2034239309 hasConcept C120770815 @default.
• W2034239309 hasConcept C123012128 @default.
• W2034239309 hasConcept C126322002 @default.
• W2034239309 hasConcept C134018914 @default.
• W2034239309 hasConcept C170493617 @default.
• W2034239309 hasConcept C181199279 @default.
• W2034239309 hasConcept C202751555 @default.
• W2034239309 hasConcept C203014093 @default.
• W2034239309 hasConcept C2776914184 @default.
• W2034239309 hasConcept C2776992346 @default.
• W2034239309 hasConcept C2777622882 @default.
• W2034239309 hasConcept C2778078955 @default.
• W2034239309 hasConcept C2779591629 @default.
• W2034239309 hasConcept C2780972559 @default.
• W2034239309 hasConcept C519581460 @default.
• W2034239309 hasConcept C55493867 @default.
• W2034239309 hasConcept C71924100 @default.
• W2034239309 hasConcept C86803240 @default.
• W2034239309 hasConcept C98274493 @default.
• W2034239309 hasConceptScore W2034239309C120770815 @default.
• W2034239309 hasConceptScore W2034239309C123012128 @default.
• W2034239309 hasConceptScore W2034239309C126322002 @default.
• W2034239309 hasConceptScore W2034239309C134018914 @default.
• W2034239309 hasConceptScore W2034239309C170493617 @default.
• W2034239309 hasConceptScore W2034239309C181199279 @default.
• W2034239309 hasConceptScore W2034239309C202751555 @default.
• W2034239309 hasConceptScore W2034239309C203014093 @default.
• W2034239309 hasConceptScore W2034239309C2776914184 @default.
• W2034239309 hasConceptScore W2034239309C2776992346 @default.
• W2034239309 hasConceptScore W2034239309C2777622882 @default.
• W2034239309 hasConceptScore W2034239309C2778078955 @default.
• W2034239309 hasConceptScore W2034239309C2779591629 @default.
• W2034239309 hasConceptScore W2034239309C2780972559 @default.
• W2034239309 hasConceptScore W2034239309C519581460 @default.
• W2034239309 hasConceptScore W2034239309C55493867 @default.
• W2034239309 hasConceptScore W2034239309C71924100 @default.
• W2034239309 hasConceptScore W2034239309C86803240 @default.
• W2034239309 hasConceptScore W2034239309C98274493 @default.
• W2034239309 hasIssue "5" @default.
• W2034239309 hasLocation W20342393091 @default.
• W2034239309 hasLocation W20342393092 @default.
• W2034239309 hasOpenAccess W2034239309 @default.
• W2034239309 hasPrimaryLocation W20342393091 @default.
• W2034239309 hasRelatedWork W1509822090 @default.
• W2034239309 hasRelatedWork W1991289091 @default.
• W2034239309 hasRelatedWork W2034239309 @default.
• W2034239309 hasRelatedWork W2048014021 @default.
• W2034239309 hasRelatedWork W2091193879 @default.

• next