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- W2034240382 abstract "Interleukin-1β (IL-1), a cytokine released from inflammatory cells, is thought to be involved in the anorexia associated with severe infection. To assess a possible role of the amino acid sequence found in the supposed IL-1 receptor binding sites, we determined the antagonistic effects of α-melanocytc-stimulating hormone (MSH) and the carboxyl-terminal tripeptide of α-MSH-(11–13) (α-MSH-(11–13)) on the anorexia induced by intracerebroventricular (i.c.v.) administration of 0.5 pmol IL-1. The parent α-MSH molecule completely prevented the induction of anorexia by IL-1 at both doses tested, 0.5 and 5.0 pmol. In contrast, α-MSH-(11–13) prevented the IL-1-induccd anorexia only at 5.0 pmol, but not at 0.5 pmol. Intracerebroventricular injection of 5 pmol of the parent α-MSH molecule alone temporarily decreased food consumption at 1–2 h; 5.0 pmol of α-MSH-(11–13) alone did not affect food consumption. These data indicate that α-MSH can antagonize the anorexic effects of IL-1. The carboxyl-terminal tripeptide portion of α-MSH may be important for the antagonistic action of α-MSH on the anorexia induced by IL-1." @default.
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- W2034240382 date "1992-09-01" @default.
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- W2034240382 title "Carboxyl-terminal tripeptide of α-melanocyte-stimulating hormone antagonizes interleukin-1-induced anorexia" @default.
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- W2034240382 doi "https://doi.org/10.1016/0014-2999(92)90738-p" @default.
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