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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034242745> ?p ?o ?g. }

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• W2034242745 abstract "Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon assays (IC50 (1b) <10 nM; EC50 (1b) = 34 nM) as well as good stability towards human liver microsomes (HLM t1/2 = 59 min)." @default.
• W2034242745 created "2016-06-24" @default.
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• W2034242745 date "2008-09-01" @default.
• W2034242745 modified "2023-10-18" @default.
• W2034242745 title "Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase" @default.
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• W2034242745 doi "https://doi.org/10.1016/j.bmcl.2008.08.017" @default.
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